DNA damage: ubiquitin marks the spot

被引：70

作者：

Bennett, Eric J. ^{[1
]}

Harper, J. Wade ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2008年 / 15卷 / 01期

关键词：

D O I：

10.1038/nsmb0108-20

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

DNA damage activates signaling cascades driven by the ATM-ATR protein kinases, culminating in the recruitment of repair proteins to the damage site through poorly understood mechanisms. Now a flurry of papers reveals how ATM-dependent phosphorylation of mediator and chromatin-associated proteins at sites of double-strand breaks promotes ubiquitylation of local nucleosomes, thereby eliciting a powerful signal for recruitment of repair complexes to the damage site.

引用

页码：20 / 22

页数：3

共 25 条

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