The effects of treadmill exercise in animal models of Parkinson's disease: A systematic review

被引：17
作者：
Ferreira, Ana Flavia F. [1 ]
Binda, Karina Henrique [2 ,3 ]
Real, Caroline Cristiano [3 ,4 ]
机构：
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, Lab Cellular Neurobiol, Sao Paulo, SP, Brazil
[2] Univ Sao Paulo, Inst Biomed Sci, Dept Anat, Lab Funct Neuroanat Pain, Sao Paulo, SP, Brazil
[3] Aarhus Univ, Translat Neuropsychiat Unit TNU, Aarhus, Denmark
[4] Univ Sao Paulo, Fac Med FMUSP, Sao Paulo, SP, Brazil
来源：
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS | 2021年 / 131卷
基金：
巴西圣保罗研究基金会;
关键词：
Treadmill exercise; Neuroplasticity; Neuroprotection; Dopaminergic system; 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE-LESIONED MOUSE MODEL; DOPAMINERGIC NEURONAL LOSS; ENDURANCE EXERCISE; RAT MODEL; RECEPTOR EXPRESSION; MOTOR DEFICITS; BEHAVIORAL ASYMMETRY; DEPRESSIVE SYMPTOMS; NEUROTROPHIC FACTOR; FORCED EXERCISE;
D O I：
10.1016/j.neubiorev.2021.10.019
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
Parkinson's disease (PD) is a progressive disabling brain disorder. Physical exercise has been shown to alleviate the symptoms of PD and, consequently, improve patient quality of life. Exercise mechanisms involved in beneficial effects on PD have been widely investigated. This study aims to systematically review the literature on the use of treadmill exercise in PD animal models. The study was conducted according to Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA). Searches were conducted in MEDLINE, EMBASE, and ISI databases. In total, 78 studies were included. The dopaminergic system, behavior, neuroplasticity, neuroinflammation, mitochondria, and musculoskeletal systems were some of the outcomes evaluated by the selected studies. Based on the systematic review center for laboratory animal experimentation (SYRCLE) RoB tool, the methodologies revealed a high risk of bias and lack of information about study design, which needs attention for data reproducibility. This review can guide future studies that aim to fill existing gaps regarding the effects of treadmill exercise in PD animal models.
引用
收藏
页码：1056 / 1075
页数：20
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