Inflammatory single nucleotide polymorphisms and the risk of atrial fibrillation: a case control study

被引：8

作者：

Henningsen, Kristoffer M. ^{[1
,2
,3
]}

Olesen, Morten S. ^{[1
,3
]}

Ravn, Lasse S. ^{[1
]}

Dixen, Ulrik ^{[4
]}

Haunsoe, Stig ^{[1
,3
]}

Bruunsgaard, Helle ^{[5
,6
]}

Svendsen, Jesper H. ^{[1
,3
,7
]}

机构：

[1] Univ Copenhagen, Ctr Heart, Dept Cardiol, Rigshosp, DK-2100 Copenhagen, Denmark

[2] Univ Calif San Francisco, Dept Cardiol, San Francisco, CA 94143 USA

[3] Danish Natl Res Fdn Ctr Cardiac Arrhythmia DARC, Copenhagen, Denmark

[4] Univ Copenhagen, Hvidovre Hosp, Dept Cardiol, DK-2100 Copenhagen, Denmark

[5] Univ Copenhagen, Rigshosp, Ctr Inflammat & Metab, Dept Infect Dis, DK-2100 Copenhagen, Denmark

[6] Univ Copenhagen, Rigshosp, Dept Clin Immunol, DK-2100 Copenhagen, Denmark

[7] Univ Copenhagen, Fac Hlth Sci, Dept Surg & Med, DK-2100 Copenhagen, Denmark

来源：

INFLAMMATION RESEARCH | 2011年 / 60卷 / 03期

基金：

新加坡国家研究基金会;

关键词：

Cardiology; Gene expression; INTERLEUKIN-1; ONSET;

D O I：

10.1007/s00011-010-0285-2

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Systemic inflammation is associated with atrial fibrillation (AF) and inflammatory processes are involved in the pathophysiology of AF. We hypothesized that genetic polymorphisms, which determine the rate of inflammatory cytokines, are associated with increased risk of AF. We included 158 patients with AF and 188 healthy controls. All patients were genotyped for common single nucleotide polymorphisms (SNPs) in selected inflammatory genes. A case-control analysis of the investigated SNPs (IL1A-889, TNF-308, IL1B-511, IL10-592, IL10-1082, IL18-137 and IL18-607) revealed no significant differences in the frequencies of genotypes between the AF patients and the healthy controls.

引用

页码：209 / 211

页数：3

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