A novel small molecule fluorescent sensor for Zn2+ based on pyridine-pyridone scaffold

被引：16

作者：

Hagimori, Masayori ^{[2
]}

Mizuyama, Naoko ^{[3
]}

Yamaguchi, Yasuchika ^{[2
]}

Saji, Hideo ^{[4
]}

Tominaga, Yoshinori ^{[1
]}

机构：

[1] Nagasaki Univ, Fac Environm Studies, Nagasaki 8528521, Japan

[2] Nagasaki Int Univ, Fac Pharmaceut Sci, Sasebo 8593298, Japan

[3] Saga Univ Hosp, Dept Hosp Pharm, Saga 8498521, Japan

[4] Kyoto Univ, Grad Sch Pharmaceut Sci, Sakyo Ku, Kyoto 6068501, Japan

来源：

TALANTA | 2011年 / 83卷 / 05期

关键词：

Zn2+; Fluorescent sensor; Pyridine-pyridone; Small molecule; Water-soluble; I-CONVERTING-ENZYME; INTRACELLULAR ZINC; PROBE; ACID; METALLONEUROCHEMISTRY; NEUROBIOLOGY; SECRETION; APOPTOSIS; DISEASE; BIOLOGY;

D O I：

10.1016/j.talanta.2010.12.003

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The development of a water-soluble and small molecular weight fluorescent probe. 3-(4-methoxyphenyl)-4-(methylsulfanyl)-6-(pyridin-2-yl)pyridin-2(1H)-one (3), for detecting Zn2+ based on pyridine-pyridone skeleton is reported. We observed a clear chelation enhanced fluorescence effect of 3 in the presence of Zn2+. Other fluorescent properties of 3 are discussed. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：1730 / 1735

页数：6

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