Potent virucidal effect of pheophorbide a and pyropheophorbide a on enveloped viruses

被引：21

作者：

Bouslama, Lamjed ^{[2
]}

Hayashi, Kyoko ^{[1
]}

Lee, Jung-Bum ^{[1
]}

Ghorbel, Abdelwahed ^{[2
]}

Hayashi, Toshimitsu ^{[1
]}

机构：

[1] Toyama Univ, Grad Sch Med & Pharmaceut Sci Res, Toyama 9300194, Japan

[2] Ctr Biotechnol Borj Cedria, Hammam Lif 2050, Tunisia

来源：

JOURNAL OF NATURAL MEDICINES | 2011年 / 65卷 / 01期

关键词：

Cactus; Virucidal effect; Pheophorbide a; Pyropheophorbide a; Enveloped virus; OPUNTIA; METABOLISM;

D O I：

10.1007/s11418-010-0468-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In this study, we evaluated the inhibitory effect of ethanol and aqueous extracts from a stem of Opuntia ficus indica on replication of three kinds of viruses: two enveloped viruses [herpes simplex virus type 2 (HSV-2), influenza A virus (IFV-A)], and one non-enveloped virus [poliovirus type 1 (PV-1)]. Only ethanol extract from the cactus stem showed significant antiviral activity in vitro. Two chlorophyll derivatives, pheophorbide a and pyropheophorbide a, were isolated as active substances exhibiting potent virucidal effects on HSV-2 and IFV-A, but no activity against PV-1 was observed. These findings suggest that these active compounds might recognize specific glycoproteins of enveloped viruses, precluding their binding to host cell receptors and inhibiting viral infections.

引用

页码：229 / 233

页数：5

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