A Case of Newly Developed Pemphigus Foliaceus and Possible Association with Alternative Bee-Venom Therapy

被引：2

作者：

Yoo, Seung Ah ^{[1
]}

Park, Hyo Eun ^{[1
]}

Kim, Miri ^{[1
]}

机构：

[1] Catholic Univ Korea, Yeouido St Marys Hosp, Coll Med, Dept Dermatol, 10 63 Ro, Seoul 07345, South Korea

来源：

ANNALS OF DERMATOLOGY | 2021年 / 33卷 / 05期

关键词：

Autoimmune diseases; Bee venoms; Immunology; Pemphigus; VULGARIS;

D O I：

10.5021/ad.2021.33.5.467

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Bee-venom is composed of a variety of peptides, enzymes, and biogenic amines, and is demonstrated to have both anti-inflammatory and immune-stimulatory effects in human body. Pemphigus foliaceus (PF) is a variant of pemphigus, which is a rare autoimmune bullous disease presenting with erythematous scaly crusted plaques. Although the exact pathogenesis was not identified, there have been three case reports of autoimmune disorders associated with bee-venom. In this case, a 64-year-old female was diagnosed with PF, which was developed after alternative bee-venom acupuncture therapy. We assumed that the bee-venom caused the diseases through a temporal relationship and its known immunostimulatory action. Herein, we suggest that physicians recognize the possibility of bee-venom stimulating the immune system and triggering various autoimmune diseases including pemphigus. (Ann Dermatol 33(5) 467 similar to 469, 2021)

引用

页码：467 / 469

页数：3

共 11 条

[1] High-dose bee venom exposure induces similar tolerogenic B-cell responses in allergic patients and healthy beekeepers [J].