Iron parameters in pregnant women with beta-thalassaemia minor combined with iron deficiency anaemia compared to pregnant women with iron deficiency anaemia alone demonstrate the safety of iron supplementation in beta-thalassaemia minor during pregnancy

被引:2
作者
Chen, Niankun [1 ]
Li, Zhongjun [2 ]
Huang, Yingying [3 ]
Xiao, Chaoqun [3 ]
Shen, Xinyang [3 ]
Pan, Shumin [3 ]
Su, Qiongqiong [4 ]
Wang, Zhijian [3 ]
机构
[1] Sun Yat Sen Univ, Affiliated Hosp 7, Shenzhen, Peoples R China
[2] Southern Med Univ, Dongguan Peoples Hosp, Dept Obstet & Gynecol, Dongguan, Peoples R China
[3] Southern Med Univ, Nanfang Hosp, Dept Obstet & Gynecol, 1838 Guangzhou Ave, Guangzhou 510515, Peoples R China
[4] Southern Med Univ, Nanfang Hosp, Dept Hematol, Guangzhou, Peoples R China
关键词
beta-thalassaemia minor; GDF15; hepcidin; IDA; iron metabolism; iron supplementation; pregnancy; SOLUBLE TRANSFERRIN RECEPTOR; GROWTH-DIFFERENTIATION FACTOR-15; ERYTHROPOIESIS; HOMEOSTASIS; PREVALENCE; METABOLISM; ABSORPTION; DIAGNOSIS; CORRELATE; HEPCIDIN;
D O I
10.1111/bjh.17827
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
In patients with beta-thalassaemia intermedia or major, hepcidin induces iron overload by continuously promoting iron absorption. There have been no studies in pregnant women with beta-thalassaemia minor combined with iron deficiency anaemia (IDA), examining whether hepcidin is inhibited by GDF15, as may occur in patients with beta-thalassaemia intermedia or major, or whether the iron metabolism characteristics and the effect of iron supplementation are consistent with simple IDA in pregnancy. We compared and analysed routine blood parameters, iron metabolism parameters, the GDF15 levels, and the hepcidin levels among four groups, namely the beta-thalassaemia (beta) + IDA, beta, IDA, and normal groups. In addition, the beta + IDA and IDA groups received iron supplementation for four weeks. We found no statistically significant correlation between hepcidin and GDF15 in any group, but a positive correlation was observed between hepcidin and ferritin. After iron supplementation, the routine blood parameters and iron metabolism parameters in the beta + IDA group were improved, and the hepcidin content was significantly increased. These results suggest that in pregnant women with beta-thalassaemia minor, hepcidin functions normally to maintain iron homeostasis, and that iron supplementation is effective and safe.
引用
收藏
页码:390 / 396
页数:7
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