Genetic Testing to Guide Warfarin Dosing: Impact of Direct Oral Anticoagulants

被引:4
作者
Lentz, S. R. [1 ]
机构
[1] Univ Iowa, Dept Internal Med, Carver Coll Med, Iowa City, IA 52242 USA
关键词
PHARMACOGENETICS; GENOTYPES;
D O I
10.1002/cpt.395
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Despite rapid growth in the use of direct oral anticoagulants (DOACs), warfarin remains a widely prescribed anticoagulant drug. It is likely that the overall use of warfarin will continue to decline, but not completely disappear, as indications for DOACs expand. This changing anticoagulation landscape, along with the likelihood that personalized genomic information will become increasingly available, has several implications for the future of warfarin dosing strategies.
引用
收藏
页码:128 / 130
页数:4
相关论文
共 10 条
  • [1] Pharmacogenetics and oral antithrombotic drugs
    Baker, William L.
    Johnson, Samuel G.
    [J]. CURRENT OPINION IN PHARMACOLOGY, 2016, 27 : 38 - 42
  • [2] Genetics informatics trial (GIFT) of warfarin to prevent deep vein thrombosis (DVT): rationale and study design
    Do, E. J.
    Lenzini, P.
    Eby, C. S.
    Bass, A. R.
    McMillin, G. A.
    Stevens, S. M.
    Woller, S. C.
    Pendleton, R. C.
    Anderson, J. L.
    Proctor, P.
    Nunley, R. M.
    Davila-Roman, V.
    Gage, B. F.
    [J]. PHARMACOGENOMICS JOURNAL, 2012, 12 (05) : 417 - 424
  • [3] Poor warfarin dose prediction with pharmacogenetic algorithms that exclude genotypes important for African Americans
    Drozda, Katarzyna
    Wong, Shan
    Patel, Shitalben R.
    Bress, Adam P.
    Nutescu, Edith A.
    Kittles, Rick A.
    Cavallari, Larisa H.
    [J]. PHARMACOGENETICS AND GENOMICS, 2015, 25 (02) : 73 - 81
  • [4] Clinical Pharmacogenetics Implementation Consortium Guidelines for CYP2C9 and VKORC1 Genotypes and Warfarin Dosing
    Johnson, J. A.
    Gong, L.
    Whirl-Carrillo, M.
    Gage, B. F.
    Scott, S. A.
    Stein, C. M.
    Anderson, J. L.
    Kimmel, S. E.
    Lee, M. T. M.
    Pirmohamed, M.
    Wadelius, M.
    Klein, T. E.
    Altman, R. B.
    [J]. CLINICAL PHARMACOLOGY & THERAPEUTICS, 2011, 90 (04) : 625 - 629
  • [5] Antithrombotic Therapy for VTE Disease CHEST Guideline and Expert Panel Report
    Kearon, Clive
    Akl, Elie A.
    Ornelas, Joseph
    Blaivas, Allen
    Jimenez, David
    Bounameaux, Henri
    Huisman, Menno
    King, Christopher S.
    Morris, Timothy A.
    Sood, Namita
    Stevens, Scott M.
    Vintch, Janine R. E.
    Wells, Philip
    Woller, Scott C.
    Moores, Lisa
    [J]. CHEST, 2016, 149 (02) : 315 - 352
  • [6] A Pharmacogenetic versus a Clinical Algorithm for Warfarin Dosing
    Kimmel, Stephen E.
    French, Benjamin
    Kasner, Scott E.
    Johnson, Julie A.
    Anderson, Jeffrey L.
    Gage, Brian F.
    Rosenberg, Yves D.
    Eby, Charles S.
    Madigan, Rosemary A.
    McBane, Robert B.
    Abdel-Rahman, Sherif Z.
    Stevens, Scott M.
    Yale, Steven
    Mohler, Emile R., III
    Fang, Margaret C.
    Shah, Vinay
    Horenstein, Richard B.
    Limdi, Nita A.
    Muldowney, James A. S., III
    Gujral, Jaspal
    Delafontaine, Patrice
    Desnick, Robert J.
    Ortel, Thomas L.
    Billett, Henny H.
    Pendleton, Robert C.
    Geller, Nancy L.
    Halperin, Jonathan L.
    Goldhaber, Samuel Z.
    Caldwell, Michael D.
    Califf, Robert M.
    Ellenberg, Jonas H.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2013, 369 (24) : 2283 - 2293
  • [7] Genetic Determinants of Dabigatran Plasma Levels and Their Relation to Bleeding
    Pare, Guillaume
    Eriksson, Niclas
    Lehr, Thorsten
    Connolly, Stuart
    Eikelboom, John
    Ezekowitz, Michael D.
    Axelsson, Tomas
    Haertter, Sebastian
    Oldgren, Jonas
    Reilly, Paul
    Siegbahn, Agneta
    Syvanen, Ann-Christine
    Wadelius, Claes
    Wadelius, Mia
    Zimdahl-Gelling, Heike
    Yusuf, Salim
    Wallentin, Lars
    [J]. CIRCULATION, 2013, 127 (13) : 1404 - +
  • [8] A Randomized Trial of Genotype-Guided Dosing of Warfarin
    Pirmohamed, Munir
    Burnside, Girvan
    Eriksson, Niclas
    Jorgensen, Andrea L.
    Toh, Cheng Hock
    Nicholson, Toby
    Kesteven, Patrick
    Christersson, Christina
    Wahlstrom, Bengt
    Stafberg, Christina
    Zhang, J. Eunice
    Leathart, Julian B.
    Kohnke, Hugo
    Maitland-van der Zee, Anke H.
    Williamson, Paula R.
    Daly, Ann K.
    Avery, Peter
    Kamali, Farhad
    Wadelius, Mia
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2013, 369 (24) : 2294 - 2303
  • [9] Trends in Prescribing Oral Anticoagulants in Canada, 2008-2014
    Weitz, Jeffrey I.
    Semchuk, William
    Turpie, Alexander G. G.
    Fisher, William D.
    Kong, Cindy
    Ciaccia, Antonio
    Cairns, John A.
    [J]. CLINICAL THERAPEUTICS, 2015, 37 (11) : 2506 - 2514
  • [10] Overview of the New Oral Anticoagulants Opportunities and Challenges
    Yeh, Calvin H.
    Hogg, Kerstin
    Weitz, Jeffrey I.
    [J]. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2015, 35 (05) : 1056 - 1065