A convenient synthesis of the beraprost intermediate: A useful method for introducing a C3 unit at the benzyl position

被引：27
作者：
Higuchi, K
Sawada, K
Nambu, H
Shogaki, T
Kita, Y
机构：
[1] Osaka Univ, Grad Sch Pharmaceut Sci, Suita, Osaka 5650871, Japan
[2] Sawai Pharmaceut Co Ltd, Asahi Ku, Osaka 5350005, Japan
来源：
ORGANIC LETTERS | 2003年 / 5卷 / 20期
关键词：
D O I：
10.1021/ol035371+
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The Heck reaction is a more efficient and reliable method than previous ones for introducing a C3 unit at the benzyl position for the synthesis of Beraprost. Especially, trialkylated long-chain amines such as (n-C8H17)(3)N and (n-C12H25)(3)N resulted in good yields. This development will be used for the industrial synthesis of Beraprost.
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收藏
页码：3703 / 3704
页数：2
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