Background: Epoprostenol infusion is the strongest and most convincing therapeutic strategy for severe pulmonary arterial hypertension (PAH). This study investigated the gastrointestinal side effects of epoprostenol. Methods and Results: The study group of 12 patients treated with epoprostenol (epoprostenol group) and 4 patients without epoprostenol (control group) underwent stomach barium examination, which revealed that the prevalence of giant fold gastritis was significantly higher in the patients treated with epoprostenol (75% in epoprostenol group vs. 0% in control group; P=0.019). Conclusions: Giant fold gastritis may be an important side effect of epoprostenol infusion.
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Univ Calif, Dept Med, San Diego, CA USAUniv Calif, Dept Med, San Diego, CA USA
Rubin, Lewis J.
Galie, Nazzareno
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Bologna Univ Hosp, Inst Cardiol, Bologna, ItalyUniv Calif, Dept Med, San Diego, CA USA
Galie, Nazzareno
Barst, Robyn J.
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Columbia Univ, Div Pediat Cardiol, New York, NY USAUniv Calif, Dept Med, San Diego, CA USA
Barst, Robyn J.
Fleming, Thomas R.
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Univ Washington, Dept Biostat, Seattle, WA USAUniv Calif, Dept Med, San Diego, CA USA
Fleming, Thomas R.
Frost, Adaani
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Sect Pulm & Crit Care, Dept Med, Baylor Coll Med, Houston, TX USAUniv Calif, Dept Med, San Diego, CA USA
Frost, Adaani
Engel, Peter
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Christ Hosp, Pulm Hypertens Program, Cincinnati, OH USAUniv Calif, Dept Med, San Diego, CA USA
Engel, Peter
Kramer, Mordechai R.
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机构:Univ Calif, Dept Med, San Diego, CA USA
Kramer, Mordechai R.
Serdarevic-Pehar, Marjana
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机构:
Pulm Inst, Rabin Med Ctr, Petah Tikvcz, IsraelUniv Calif, Dept Med, San Diego, CA USA
Serdarevic-Pehar, Marjana
Layton, Gary R.
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机构:
Pfizer Ltd, Worldwide Pharmaceut Operat, Sandwich, Kent, EnglandUniv Calif, Dept Med, San Diego, CA USA
Layton, Gary R.
Sitbon, Olivier
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机构:Univ Calif, Dept Med, San Diego, CA USA
Sitbon, Olivier
Badesch, David B.
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机构:
Univ Colorado, Div Pulm Sci & Crit Care Med, Denver, CO USA
Univ Colorado, Pulm Hypertens Program, Denver, CO USAUniv Calif, Dept Med, San Diego, CA USA