Preservation on calcium homeostasis is involved in mitochondrial protection of Limonium sinense against liver damage in mice

被引：11

作者：

Tang, Xin-Hui ^{[1
,2
]}

Chen, Jin ^{[3
,4
]}

Yang, Xiao-Lan ^{[2
]}

Yan, Li-Fang ^{[1
,2
]}

Gao, Jing ^{[1
]}

机构：

[1] Jiangsu Univ, Sch Pharm, Zhenjiang 212013, Peoples R China

[2] Yancheng Teachers Univ, Jiangsu Prov Key Lab Coastal Wetland Bioresources, Yancheng 224002, Peoples R China

[3] Nanjing Univ, Sch Life Sci, Nanjing 210009, Peoples R China

[4] Univ Cent Florida, Burnett Sch Biomed Sci, Orlando, FL 32816 USA

来源：

PHARMACOGNOSY MAGAZINE | 2010年 / 6卷 / 23期

关键词：

D-galactosamine; Limonium sinense (Girard) Ktze; lipopolysaccharide; mitochondrial Ca2+-ATPase activity; mitochondrial Ca2+ overload; CARBON-TETRACHLORIDE; PERMEABILITY TRANSITION; ACID; HEPATOPROTECTION; INTOXICATION; INHIBITION; MECHANISMS; APOPTOSIS; CULTURE; INJURY;

D O I：

10.4103/0973-1296.66935

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Mechanisms underlying the mitochondrial protection of Limonium sinense extracts (LSE) was studied in lipopolysaccharide and D-galactosamine (LPS/D-GalN) intoxicated mice. It was found that increased activities of serum aspartate aminotransferase and alanine aminotransferase induced by LPS/D-GalN were significantly inhibited by pretreatment with LSE. The obvious disruption of membrane potential, intramitochondrial Ca2+ overload and suppression in mitochondrial Ca2+-ATPase activity induced by LPS/D-GalN were significantly blocked by pretreatment with LSE. It was concluded that mechanisms underlying protection of LSE against liver mitochondria damage might be related to the preservation on mitochondrial Ca2+ homeostasis through the preservation on mitochondrial Ca2+-ATPase activity.

引用

页码：191 / 197

页数：7

共 26 条

[1] LIVER AND SKELETAL-MUSCLE MITOCHONDRIAL-FUNCTION FOLLOWING BURN INJURY [J].

APRILLE, JR ;

HOM, JA ;

RULFS, J .

JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE, 1977, 17 (04) :279-288

[2]

BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3

[3] Apoptosis: The nexus of liver injury and fibrosis [J].

Canbay, A ;

Friedman, S ;

Gores, GJ .

HEPATOLOGY, 2004, 39 (02) :273-278

[4] The hepatoprotective effects of Limonium sinense against carbon tetrachloride and β-D-galactosamine intoxication in rats [J].

Chaung, SS ;

Lin, CC ;

Lin, J ;

Yu, KH ;

Hsu, YF ;

Yen, MH .

PHYTOTHERAPY RESEARCH, 2003, 17 (07) :784-791

[5] Schisandrin B decreases the sensitivity of mitochondria to calcium ion-induced permeability transition and protects against carbon tetrachloride toxicity in mouse livers [J].

Chiu, Po Yee ;

Leung, Hoi Yan ;

Siu, Ada Hoi Ling ;

Poon, Michel Kong Tat ;

Ko, Kam Ming .

BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2007, 30 (06) :1108-1112

[6]

Duchen Michael R., 2004, Molecular Aspects of Medicine, V25, P365, DOI 10.1016/j.mam.2004.03.001

[7] Attenuation of liver normothermic ischemia-reperfusion injury by preservation of mitochondrial functions with S-15176, a potent trimetazidine derivative [J].

Elimadi, A ;

Sapena, R ;

Settaf, A ;

Le Louet, H ;

Tillement, JP ;

Morin, D .

BIOCHEMICAL PHARMACOLOGY, 2001, 62 (04) :509-516

[8] RHODAMINE-123 AS A PROBE OF TRANSMEMBRANE POTENTIAL IN ISOLATED RAT-LIVER MITOCHONDRIA - SPECTRAL AND METABOLIC PROPERTIES [J].

EMAUS, RK ;

GRUNWALD, R ;

LEMASTERS, JJ .

BIOCHIMICA ET BIOPHYSICA ACTA, 1986, 850 (03) :436-448

[9] Mechanism underlying mitochondrial protection of asiatic acid against hepatotoxicity in mice [J].

Gao, J ;

Chen, J ;

Tang, XH ;

Pan, LY ;

Fang, F ;

Xu, LZ ;

Zhao, XN ;

Xu, Q .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 2006, 58 (02) :227-233

[10] Calcium and mitochondria [J].

Gunter, TE ;

Yule, DI ;

Gunter, KK ;

Eliseev, RA ;

Salter, JD .

FEBS LETTERS, 2004, 567 (01) :96-102

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