The Effect of 3′,4′-Dihydroxyflavonol on Lipid Peroxidation in Rats with Cerebral Ischemia Reperfusion Injury

被引：22
作者：
Caliskan, Merve [1 ]
Mogulkoc, Rasim [1 ]
Baltaci, Abdulkerim Kasim [1 ]
Menevse, Esma [2 ]
机构：
[1] Selcuk Univ, Fac Med, Dept Physiol, Konya, Turkey
[2] Selcuk Univ, Fac Med, Dept Biochem, Konya, Turkey
来源：
NEUROCHEMICAL RESEARCH | 2016年 / 41卷 / 07期
关键词：
Brain ischaemia-reperfusion; 3; 4; '-dihydroxyflavonol; Free radicals; Rat; INDUCED OXIDATIVE STRESS; BRAIN-INJURY; ISCHEMIA/REPERFUSION INJURY; MYOCARDIAL-ISCHEMIA; FOREBRAIN ISCHEMIA; ANTIOXIDANT; MECHANISMS; HIPPOCAMPUS; MODULATION; INHIBITION;
D O I：
10.1007/s11064-016-1889-x
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The aim of present study was to determine the effect of 3',4'-dihydroxyflavonol (DiOHF) on lipid peroxidation in experimental brain ischemia-reperfusion in rats. Present study was performed on the 34 male Wistar-albino rats, weigth 350-400 g. Experiment groups were designed as 1-Sham; 2-Ischemia-reperfusion; animal were anesthesized and carotid arteried were clemped for 20 min and reperfusion (7 days). 3-DiOHF + Ischemia-reperfusion; DiOHF was given to animals as 10 mg/kg by intraperitoneal. 4- Ischemia + DiOHF + Reperfusion; 5- Ischemia-reperfusion + DiOHF. Blood samples and serebral cortex were analysed for malondyaldehyde (MDA), NO (nitric oxide), xanthine oxidase (XO), glutathione (GSH) and glutathione peroxidase (GPx). Blood MDA levels were significantly higher ischemia-reperfusion groups (P < 0.005). However, DiOHF inhibited MDA. Ischemia-reperfusion led to increased XO and NO but DiOHF supplementation reduced NO and XO. DiOHF increased GSH and GPx levels compared to ischemia-reperfusion group. All together, our present study showed that intraperitoneal DiOHF supplementation has protective effect on brain ischaemia-reperfusion injury in rat.
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收藏
页码：1732 / 1740
页数：9
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