A practical catalytic method for preparing highly substituted cyclobutanes and cyclobutenes

被引：131

作者：

Inanaga, K ^{[1
]}

Takasu, K ^{[1
]}

Ihara, M ^{[1
]}

机构：

[1] Tohoku Univ, Grad Sch Pharmaceut Sci, Dept Organ Chem, Sendai, Miyagi 9808578, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2005年 / 127卷 / 11期

关键词：

D O I：

10.1021/ja042661s

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Tf2NH, an organic acid, efficiently catalyzes (2 + 2) cycloaddition reactions of silyl enol ethers with acrylates or propiolate. The process affords highly substituted cyclobutanes in high yield with high stereoselectivity under practical and environmentally benign conditions. Application for the formation of terpene skeletons and multigram synthesis of four-membered carbocycles were demonstrated. Copyright © 2005 American Chemical Society.

引用

页码：3668 / 3669

页数：2

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