How Patients and Providers Weigh the Risks and Benefits of Long-Term Opioid Therapy for Cancer Pain

被引:5
作者
Giannitrapani, Karleen F. [1 ,2 ]
Fereydooni, Soraya [1 ,2 ]
Silveira, Maria J. [3 ,4 ]
Azarfar, Azin [1 ,5 ]
Glassman, Peter A. [6 ,7 ]
Midboe, Amanda [1 ,2 ]
Zenoni, Maria [8 ]
Becker, William C. [8 ,9 ]
Lorenz, Karl A. [1 ,2 ]
机构
[1] Ctr Innovat Implementat Ci2i, VA Palo Alto Hlth Care Syst, 795 Willow Rd,152 MPD, Menlo Pk, CA 94025 USA
[2] Stanford Univ, Sch Med, Stanford, CA 94305 USA
[3] Ann Arbor VA Hlth Care Syst, Geriatr Res Educ Clin Ctr GRECC, Ann Arbor, MI USA
[4] Univ Michigan, Ann Arbor, MI 48109 USA
[5] Univ Cent Florida, Orlando, FL 32816 USA
[6] VA Pharm Benefits Management Serv, Washington, DC USA
[7] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA
[8] VA Connecticut Hlth Care Syst, Pain Res Informat Multimorbid & Educ PRIME Ctr, West Haven, CT USA
[9] Yale Sch Med, New Haven, CT USA
关键词
D O I
10.1200/OP.20.00679
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
PURPOSE: To understand how patients and providers weigh the risks and benefits of long-term opioid therapy (LTOT) for cancer pain. METHODS: Researchers used VA approved audio-recording devices to record interviews. ATLAS t.i., a qualitative analysis software, was used for analysis of transcribed interview data. Participants included 20 Veteran patients and 20 interdisciplinary providers from primary care- and oncology-based practice settings. We conducted semistructured interviews and analyzed transcripts used thematic qualitative methods. Interviews explored factors that affect decision making about appropriateness of LTOT for cancer related pain. We saturated themes for providers and patients separately. RESULTS: Factors affecting patient decision-making included influence from various information sources, persuasion from trusted providers, and sometimes deferral of the decision to their provider. Relative prioritization of pain management as the focal patient concern varied with some patients describing comparatively more fear of chemotherapy than opioid analgesics, comparatively more knowledge of opioids in relation to other drugs;patients expressed a preference to spend the limited time they have with their oncologist discussing cancer treatment rather than opioid use. Factors affecting provider decision making included prognosis, patient goals, patient characteristics, and provider experience and biases. Providers differed in how they weigh the relative importance of alleviating pain or avoiding opioids in the face of treating patients with cancer and histories of substance abuse. CONCLUSION: Divergent perspectives on factors need to be considered when weighing risks and benefits. Policies and interventions should be designed to reduce variation in practice to promote equal access to adequate pain management. Improved shared decision-making initiatives will take advantage of patient decision-making factors and priorities.
引用
收藏
页码:447 / +
页数:11
相关论文
共 37 条
[1]  
van Den Beuken-Van Everdingen M.H., de Rijke J.M., Kessels A.G., Et al., Prevalence of pain in patients with cancer: A systematic review of the past 40 years, Ann Oncol, 18, pp. 1437-1449, (2007)
[2]  
Caraceni A., Hanks G., Kaasa S., Et al., Use of opioid analgesics in the treatment of cancer pain: Evidence-based recommendations from the EAPC, Lancet Oncol, 13, pp. e58-e68, (2012)
[3]  
Portenoy R., Zankhana M., Ebtesam A., Cancer Pain Management: General Principles and Risk Management for Patients Receiving Opioids, (2010)
[4]  
Corli O., Floriani I., Roberto A., Et al., Are strong opioids equally effective and safe in the treatment of chronic cancer pain? A multicenter randomized phase IV 'real life' trial on the variability of response to opioids, Ann Oncol, 27, pp. 1107-1115, (2016)
[5]  
Schmidt-Hansen M., Bennett M.I., Hilgart J., Oxycodone for cancer pain in adult patients, JAMA, 314, pp. 1282-1283, (2015)
[6]  
Bennett M., Paice J.A., Wallace M., Pain and opioids in cancer care: Benefits, risks, and alternatives, Am Soc Clin Oncol Educ Book, 37, pp. 705-713, (2017)
[7]  
Arthur J., Bruera E., Balancing opioid analgesia with the risk of nonmedical opioid use in patients with cancer, Nat Rev Clin Oncol, 16, pp. 213-226, (2019)
[8]  
Arthur J.A., Edwards T., Lu Z., Et al., Frequency, predictors, and outcomes of urine drug testing among patients with advanced cancer on chronic opioid therapy at an outpatient supportive care clinic, Cancer, 122, pp. 3732-3739, (2016)
[9]  
Childers J.W., King L.A., Arnold R.M., Chronic pain and risk factors for opioid misuse in a palliative care clinic, Am J Hosp Palliat Care, 32, pp. 654-659, (2015)
[10]  
Arthur J.A., Haider A., Edwards T., Et al., Aberrant opioid use and urine drug testing in outpatient palliative care, J Palliat Med, 19, pp. 778-782, (2016)