Nano anti-tumor necrosis factor-alpha based potentiometric sensor for tumor necrosis factor-alpha detection

被引:20
作者
Say, Ridan [1 ]
Ozkutuk, Ebru Birlik [2 ]
Unluer, Ozlem Bicen [1 ]
Ugurag, Deniz [2 ]
Ersoz, Arzu [1 ]
机构
[1] Anadolu Univ, Dept Chem, Eskisehir, Turkey
[2] Eskisehir Osmangazi Univ, Dept Chem, Eskisehir, Turkey
关键词
Potentiometric response; Rheumatoid arthritis; TNF-alpha; Nanoparticle; ANADOLUCA; AMPLIFIED LANTHANIDE LUMINESCENCE; TNF-ALPHA; SENSITIVE IMMUNOASSAY; MESSENGER-RNA; SERUM; CYTOKINES; INTERLEUKIN-1; INFLIXIMAB; ASSAYS; ELISA;
D O I
10.1016/j.snb.2014.12.063
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Tumor necrosis factor (TNF)-alpha promotes rheumatoid arthritis (RA) symptoms, including inflammation and bone erosion. The role of TNF-alpha. in RA is considered to be complex because cytokine is responsible for a wide-range of functions, such as activation of immune cells, stimulation of osteoclast differentiation, and induction of cellular apoptosis. It has appeared that the determination of TNF-alpha concentration in serum might be helpful in the staging and prognosis of diseases. In this study, a simple and sensitive potentiometric sensor method has described for the determination of TNF-alpha in serum. Influences of the membrane composition, concentration and equilibrium time have been investigated on the response properties of the electrode. The sensor has exhibited a visibly enhanced response toward TNF-alpha over the concentration range of 0.1-1.0 mg L-1 with a lower detection limit (LDL) of 0.015 mg L-1 and a slope of 62.2 mV decade(-1). The sensor has demonstrated a quick and reliable response, ability to be reproduced, as well as long-term stability. (C) 2014 Elsevier B.V. All rights reserved.
引用
收藏
页码:864 / 869
页数:6
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