Can dopamine agonists reduce the incidence and severity of OHSS in IVF/ICSI treatment cycles? A systematic review and meta-analysis

被引:58
作者
Youssef, Mohamed A. F. M. [1 ,2 ]
van Wely, Madelon [2 ]
Hassan, Mohamed Ahmed [1 ]
Al-Inany, Hesham Gaber [1 ]
Mochtar, Monique [2 ]
Khattab, Sherif [1 ]
van der Veen, Fulco [2 ]
机构
[1] Cairo Univ, Dept Obstet & Gynaecol, Cairo, Egypt
[2] Univ Amsterdam, Acad Med Ctr, Dept Obstet & Gynaecol, Ctr Reprod Med, NL-1105 AZ Amsterdam, Netherlands
关键词
OHSS; dopamine agonist; cabergoline; meta-analysis; IVF and ICSI; OVARIAN HYPERSTIMULATION SYNDROME; ENDOTHELIAL GROWTH-FACTOR; VALVULAR HEART-DISEASE; OOCYTE MATURATION; GNRH AGONIST; CABERGOLINE; PREVENTION; STIMULATION; RISK; ANGIOGENESIS;
D O I
10.1093/humupd/dmq006
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Recently, dopamine agonists were proposed as a prophylactic treatment for ovarian hyperstimulation syndrome (OHSS) in women at high risk in IVF/ICSI treatment cycles. We conducted a systematic review and meta-analysis of randomized trials comparing the prophylactic effect of the dopamine agonist, cabergoline, versus no treatment in IVF/ICSI cycles. Primary outcome was OHSS incidence per randomized woman. Secondary outcomes were live birth rate, ongoing pregnancy rate, clinical pregnancy rate and miscarriage rate. Searches (until September 2009) were conducted in MEDLINE, EMBASE, Science Direct, Cochrane Library and databases of abstracts. Four randomized trials entailing 570 women were included. There was evidence of a statistically significant reduction in the incidence of OHSS in the cabergoline group (OR 0.41, 95% CI 0.25-0.66) with an absolute risk reduction of 12% (95% CI 6.1-18.2%), but there was no statistically significant evidence of a reduction in severe OHSS (OR 0.50, 95% CI 0.20-1.26). There was no evidence for a difference in clinical pregnancy rate (OR 1.07, 95% CI 0.70-1.62) and miscarriage rate (OR 0.31, 95% CI 0.03-3.07). Prophylactic treatment with the dopamine agonist, cabergoline, reduces the incidence, but not the severity of OHSS, without compromising pregnancy outcomes.
引用
收藏
页码:459 / 466
页数:8
相关论文
共 44 条
[1]   Intravenous albumin for preventing severe ovarian hyperstimulation syndrome: a Cochrane review [J].
Aboulghar, M ;
Evers, JH ;
Al-Inany, H .
HUMAN REPRODUCTION, 2002, 17 (12) :3027-3032
[2]   Ovarian hyperstimulation syndrome: classifications and critical analysis of preventive measures [J].
Aboulghar, MA ;
Mansour, RT .
HUMAN REPRODUCTION UPDATE, 2003, 9 (03) :275-289
[3]   Prevention of OHSS [J].
Aboulghar, Mohamed .
REPRODUCTIVE BIOMEDICINE ONLINE, 2009, 19 (01) :33-42
[4]   Implantation is apparently unaffected by the dopamine agonist Cabergoline when administered to prevent ovarian hyperstimulation syndrome in women undergoing assisted reproduction treatment:: a pilot study [J].
Alvarez, Claudio ;
Alonso-Muriel, Isabel ;
Garcia, Gabriela ;
Crespo, Juana ;
Bellver, Jose ;
Simon, Carlos ;
Pellicer, Antonio .
HUMAN REPRODUCTION, 2007, 22 (12) :3210-3214
[5]   Dopamine agonist cabergoline reduces hemoconcentration and ascites in hyperstimulated women undergoing assisted reproduction [J].
Alvarez, Claudio ;
Marti-Bonmati, Luis ;
Novella-Maestre, Edurne ;
Sanz, Roberto ;
Gomez, Raul ;
Fernandez-Sanchez, Manuel ;
Simon, Carlos ;
Pellicer, Antonio .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2007, 92 (08) :2931-2937
[6]   High dose cabergoline in management of ovarian hyperstimulation syndrome [J].
Ata, Baris ;
Seyhan, Ayse ;
Orhaner, Serbulent ;
Urman, Bulent .
FERTILITY AND STERILITY, 2009, 92 (03) :1168.e1-1168.e4
[7]   Prevention of OHSS - dopamine agonists [J].
Busso, Cristiano E. ;
Garcia-Velasco, Juan ;
Gomez, Raul ;
Alvarez, Claudio ;
Simon, Carlos ;
Pellicer, Antonio .
REPRODUCTIVE BIOMEDICINE ONLINE, 2009, 19 (01) :43-51
[8]   Cabergoline reduces the early onset of ovarian hyperstimulation syndrome: a prospective randomized study [J].
Carizza, Carlos ;
Abdelmassih, Vicente ;
Abdelmassih, Soraya ;
Ravizzini, Pedro ;
Salgueiro, Lister ;
Salgueiro, Paulo Tudech ;
Jine, Lin Tao ;
Nagy, Peter ;
Abdelmassih, Roger .
REPRODUCTIVE BIOMEDICINE ONLINE, 2008, 17 (06) :751-755
[9]   Dopamine agonists and valvular heart disease [J].
Cheung, Dianne ;
Heaney, Anthony .
CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY, 2009, 16 (04) :316-320
[10]   Epidemiology and prevention of ovarian hyperstimulation syndrome (OHSS): a review [J].
Delvigne, A ;
Rozenberg, S .
HUMAN REPRODUCTION UPDATE, 2002, 8 (06) :559-577