Asc1, a WD-repeat protein, is required for hyphal development and virulence in Candida albicans

被引：16

作者：

Liu, Xiaoyan ^{[1
]}

Nie, Xinyi ^{[1
]}

Ding, Yufeng ^{[1
]}

Chen, Jiangye ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Mol Biol, Shanghai 200031, Peoples R China

来源：

ACTA BIOCHIMICA ET BIOPHYSICA SINICA | 2010年 / 42卷 / 11期

基金：

中国国家自然科学基金;

关键词：

Candida albicans; Asc1; hyphal development; virulence; AMINO-ACID STARVATION; SACCHAROMYCES-CEREVISIAE; MAMMALIAN RACK1; TRANSCRIPTION FACTOR; SIGNAL-TRANSDUCTION; FILAMENTOUS GROWTH; IN-VIVO; YEAST; KINASE; GENE;

D O I：

10.1093/abbs/gmq093

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Candida albicans is a human pathogenic fungus which can undergo a morphological transition from yeast to hyphae in response to a variety of environmental stimuli. We analyzed a C. albicans Asc1 (Absence of growth Suppressor of Cyp1) protein which is entirely composed of seven repeats of the WD domain, and is conserved from fungi to metazoan. Deleting the ASC1 in C. albicans led to a profound defect in hyphal development under hypha-inducing conditions examined. Furthermore, deletion of the ASC1 attenuated virulence of C. albicans in a mouse model of systemic infection. These data strongly suggested that the conserved WD-repeat protein Asc1 is required for morphogenesis and pathogenesis of C. albicans.

引用

页码：793 / 800

页数：8

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