Ellagitannin and flavonoid constituents from Agrimonia pilosa Ledeb. with their protein tyrosine phosphatase and acetylcholinesterase inhibitory activities

被引：40

作者：

Duc Hung Nguyen ^{[1
,2
]}

Seo, U. Min ^{[1
]}

Zhao, Bing Tian ^{[1
]}

Le, Duc Dat ^{[1
]}

Seong, Su Hui ^{[3
]}

Choi, Jae Sue ^{[3
]}

Min, Byung Sun ^{[1
]}

Woo, Mi Hee ^{[1
]}

机构：

[1] Catholic Univ Daegu, Coll Pharm, Drug Res & Dev Ctr, Gyongsan 38430, South Korea

[2] Phutho Coll Pharm, Viettri City 290000, Phutho Province, Vietnam

[3] Pukyong Natl Univ, Dept Food Sci & Nutr, Busan 48513, South Korea

来源：

BIOORGANIC CHEMISTRY | 2017年 / 72卷

基金：

新加坡国家研究基金会;

关键词：

Agrimonia pilosa; Agritannin; Agriflavone; Protein tyrosine phosphatase 1B; Acetylcholinesterase; ABSOLUTE-CONFIGURATION; RAW264.7; MACROPHAGES; OXYTROPIS-RACEMOSA; PHENOLIC-COMPOUNDS; HEPG2; CELLS; GLYCOSIDES; EXTRACT; PTP1B; 1B; TANNIN;

D O I：

10.1016/j.bioorg.2017.04.017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new ellagitannin, agritannin (1), a new flavone glycoside, agriflavone (2), and another flavone glycoside with spectroscopic data reported for the first time, kaempferol-3-O-[(S)-3-hydroxy-3-methylglutaryl (1 -> 6)]-beta-D-glucoside (3), along with 16 known compounds were isolated from the aerial parts of Agrimonia pilosa Ledeb. These compounds were evaluated for PTP1B inhibitory activity. Among them, compounds 9 and 18 displayed potential inhibitory activity against PTP1B with IC50 values of 7.14 +/- 1.75 and 7.73 +/- 0.24 mu M, respectively. In addition, compound 1 showed significant inhibitory effect with an IC50 value of 17.03 +/- 0.09 mu M. Furthermore, these compounds were tested in AChE inhibitory assays. Most of them were found to have moderate inhibitory effects, with IC50 values ranging from 60.20 +/- 1.09 to 92.85 +/- 1.12 mu M. Except compounds 3, 8, and 18 were inactive. (C) 2017 Elsevier Inc. All rights reserved.

引用

页码：293 / 300

页数：8

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