Assessment of Anti-Mullerian Hormone Level in Management of Adolescents with Polycystic Ovary Syndrome

被引:14
作者
Dursun, Fatma [1 ]
Guven, Ayla [2 ]
Yildiz, Metin [2 ]
机构
[1] Umraniye Educ & Res Hosp, Clin Pediat Endocrinol, Istanbul, Turkey
[2] Goztepe Educ & Res Hosp, Clin Pediat Endocrinol, Istanbul, Turkey
关键词
Polycystic ovary syndrome; adolescents; anti-Mullerian hormone; treatment; MENSTRUAL CYCLES; WOMEN; INSULIN; HYPERANDROGENISM; METFORMIN; THERAPY; GIRLS; AMH;
D O I
10.4274/jcrpe.2338
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective: This study was oriented to investigate the benefit of anti-Mullerian hormone (AMH) level in the management of polycystic ovary syndrome (PCOS). To assess the impact of metformin and oral contraceptives (OC) on serum AMH levels in a cohort of adolescents with PCOS. Methods: Forty-nine adolescents with PCOS were recruited to the study. Twenty-nine patients without insulin resistance were treated with OC (group 1), and 20 patients with insulin resistance were treated with metformin and OC (group 2). AMH and androgen levels were measured prior to and 6 months after the initiation of treatment. Results: AMH levels were significantly decreased with treatment in both group 1 (p=0.006) and group 2 (p=0.0048). There was a significant correlation between pre- and post-treatment AMH and left ovarian volume (pretreatment: rho=0.336, p=0.018; post-treatment: rho=0.310, p=0.034). Conclusion: This study investigated two different treatment regimens in adolescents with PCOS and revealed that AMH levels decreased with treatment. AMH levels were correlated with ovarian volume.
引用
收藏
页码:55 / 60
页数:6
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