Immunoablative therapy as a treatment for aggressive multiple sclerosis

被引：11
作者：
Atkins, H
Freedman, M
机构：
[1] Univ Ottawa, Ottawa Hosp, Multiple Sclerosis Clin, Ottawa, ON K1H 8L6, Canada
[2] Ottawa Hosp, Blood & Marrow Transplant Program, Ottawa, ON, Canada
来源：
NEUROLOGIC CLINICS | 2005年 / 23卷 / 01期
关键词：
D O I：
10.1016/j.ncl.2004.09.004
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Multiple sclerosis is an acquired autoimmune process producing chronic central nervous system inflammation and damage. Complete ablation of the immune system with high-dose cytotoxic therapy is able to rid the body of the autoreactive immunity and control the inflammatory process. Re-establishment of a naive immune system occurs after hematopoietic stem cell transplantation. Studies show clinical benefit and define the toxicities of this procedure. The results demonstrate that the natural history of aggressive multiple sclerosis can be changed.
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页码：273 / +
页数：29
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