SOX7 is associated with the suppression of human glioma by HMG-box dependent regulation of Wnt/β-catenin signaling

被引：38

作者：

Zhao, Tianshu ^{[1
]}

Yang, Hui ^{[2
]}

Tian, Yu ^{[3
]}

Xie, Qing ^{[4
]}

Lu, Yun ^{[2
]}

Wang, Yu ^{[2
]}

Su, Ning ^{[5
]}

Dong, Baijing ^{[1
]}

Liu, Xian ^{[1
]}

Wang, Ce ^{[1
]}

Jiang, Chuanlu ^{[3
]}

Liu, Xiaoqian ^{[1
]}

机构：

[1] Harbin Med Univ, Dept Neurosurg, Affiliated Hosp 4, Harbin, Peoples R China

[2] Fudan Univ, Dept Immunol, Sch Basic Med Sci, Shanghai 200433, Peoples R China

[3] Harbin Med Univ, Affiliated Hosp 2, Dept Neurosurg, Harbin, Peoples R China

[4] Capital Med Univ, Dept Clin Lab, Beijing Shijiantan Hosp, Beijing, Peoples R China

[5] Second Mil Med Univ, Shanghai Chang Zheng Hosp, Dept Gen Surg, Shanghai, Peoples R China

来源：

CANCER LETTERS | 2016年 / 375卷 / 01期

关键词：

Glioma; SOX7; Wnt/beta-catenin; Tumor suppressor; TRANSCRIPTION FACTOR; CANCER; EXPRESSION; PATHWAY; PROTEIN; GROWTH;

D O I：

10.1016/j.canlet.2016.02.044

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

SOX7 has been recently recognized as a tumor suppressor belonging to the SOX (SRY-related HMG-box) family of a transcription factor. However, its role in human gliomas is unknown. Our study showed that SOX7 expression was significantly downregulated in human gliomas. Statistical analysis showed that SOX7 suppression was associated with higher histological grades of tumors in glioma tissues. SOX7 could suppress tumor properties both in vivo and in vitro, and depletion of the HMG domain abolishes its tumor suppressive roles. In vitro assays demonstrated that SOX7 could downregulate Wnt/beta-catenin transcription and decrease the expression of Cyclin D1 and c-Myc, while the mutant SOX7 lost these functions. These results suggested that the HMG-box is a key domain of SOX7 for negatively regulating the Wnt/beta-catenin signaling pathway when functioning as a tumor suppressor in a glioma. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

引用

页码：100 / 107

页数：8

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