Significance of combined TGF-1 and survivin expression on the prognosis of patients with triple-negative breast cancer

被引：8

作者：

Liu, Nannan ^{[1
]}

Qi, Dongxue ^{[2
]}

Jiang, Jing ^{[3
]}

Zhang, Jihong ^{[3
]}

Yu, Chunyan ^{[1
,4
]}

机构：

[1] Beihua Univ, Coll Basic Med, Dept Pathol, Jilin 132013, Peoples R China

[2] Lianyungang First Peoples Hosp, Dept Pathol, Lianyungang 222000, Jiangsu, Peoples R China

[3] Beihua Univ, Dept Pathol, Affiliated Hosp, Jilin 132011, Peoples R China

[4] Beihua Univ, Coll Basic Med, Dept Pathol, 3999 Binjiang East St, Jilin 132013, Peoples R China

来源：

ONCOLOGY LETTERS | 2022年 / 23卷 / 06期

关键词：

TGF-beta; 1; survivin; triple-negative breast cancer; non-triple-negative breast cancer; immunochemistry assay; GROWTH-FACTOR-BETA; EPITHELIAL-MESENCHYMAL TRANSITION; GENE-EXPRESSION; SPLICE-VARIANTS; DOWN-REGULATION; POOR-PROGNOSIS; KAPPA-B; CELLS; TGF-BETA-1; APOPTOSIS;

D O I：

10.3892/ol.2022.13313

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Compared with other types of breast cancer, triple-negative breast cancer (TNBC) has the characteristics of rapid progression, a lack of specific molecular targets for treatment and a poor prognosis. However, based on previously published studies, TGF-beta 1 and survivin are potentially meaningful for the prognosis of patients with TNBC. The present study was therefore designed to measure and compare the expression of transforming growth factor-beta 1 (TGF-beta 1) and survivin in tissue samples of TNBC and non-TNBC patients in order to evaluate their ability as prognostic indicators. In total, 90 TNBC and 52 non-TNBC tissue specimens were selected, following which immunohistochemistry was used to detect the expression of TGF-beta 1 and survivin in the cancer tissues. Subsequently, the potential association between the expression levels of these two proteins and the clinicopathological variables was analyzed. The expression levels of TGF-beta 1 and survivin in TNBC tissues were found to be significantly higher compared with those in the non-TNBC tissues. In addition, the results of the present study demonstrated that TGF-beta 1 expression was positively associated with survivin expression in the TNBC samples, but no significant correlation was found between TGF-beta 1 and survivin expression in the non-TNBC samples. Kaplan-Meier (K-M) analysis was performed to assess the levels of TGF-beta 1 and survivin in regard to patient survival, and univariate and multivariate Cox analyses of TGF-beta 1 and survivin protein expression were performed to analyze the overall survival (OS) and progression-free survival (PFS) rates of patients with TNBC and non-TNBC. Although multivariate Cox analysis demonstrated that neither TGF-beta 1 or survivin were independent prognostic predictors of TNBC or non-TNBC, results of the K-M curve revealed that patients with TNBC with TGF-beta 1- and survivin-positive breast cancer exhibited shorter OS and PFS times. Multivariate Cox analysis demonstrated that in patients with TNBC, the combined expression of TGF-beta 1 and survivin may yield additional prognostic information, compared with patients with non-TNBC.

引用

页数：12

共 58 条

[1] Subtyping of Triple-Negative Breast Cancer: Implications for Therapy [J].

Abramson, Vandana G. ;

Lehmann, Brian D. ;

Ballinger, Tarah J. ;

Pietenpol, Jennifer A. .

CANCER, 2015, 121 (01) :8-16

[2] Overexpression of survivin in pediatric Hodgkin lymphoma tumor cells: Characterization of protein expression and splice-variants transcription profile [J].

Alejandro Lorenzetti, Mario ;

Jimena Mosna, Maria ;

Noemi De Matteo, Elena ;

Garcia Lombardi, Mercedes ;

Lorena Colli, Sandra ;

Victoria Preciado, Maria .

EXPERIMENTAL AND MOLECULAR PATHOLOGY, 2019, 108 :24-31

[3] Elucidating Prognosis and Biology of Breast Cancer Arising in Young Women Using Gene Expression Profiling [J].

Azim, Hatem A., Jr. ;

Michiels, Stefan ;

Bedard, Philippe L. ;

Singhal, Sandeep K. ;

Criscitiello, Carmen ;

Ignatiadis, Michail ;

Haibe-Kains, Benjamin ;

Piccart, Martine J. ;

Sotiriou, Christos ;

Loi, Sherene .

CLINICAL CANCER RESEARCH, 2012, 18 (05) :1341-1351

[4] TGF-β inhibition enhances chemotherapy action against triple-negative breast cancer [J].

Bhola, Neil E. ;

Balko, Justin M. ;

Dugger, Teresa C. ;

Kuba, Maria Gabriela ;

Sanchez, Violeta ;

Sanders, Melinda ;

Stanford, Jamie ;

Cook, Rebecca S. ;

Arteaga, Carlos L. .

JOURNAL OF CLINICAL INVESTIGATION, 2013, 123 (03) :1348-1358

[5] Triple-negative breast cancer: challenges and opportunities of a heterogeneous disease [J].

Bianchini, Giampaolo ;

Balko, Justin M. ;

Mayer, Ingrid A. ;

Sanders, Melinda E. ;

Gianni, Luca .

NATURE REVIEWS CLINICAL ONCOLOGY, 2016, 13 (11) :674-690

[6] Triple-negative breast cancer in the older population [J].

Boyle, P. .

ANNALS OF ONCOLOGY, 2012, 23 :7-12

[7] RETRACTED: TGF-β Regulates Survivin to Affect Cell Cycle and the Expression of EGFR and MMP9 in Glioblastoma (Retracted article. See vol. 54, pg. 7551, 2017) [J].

Chen, Wenliang ;

Zhong, Xiao ;

Wei, Yi ;

Liu, Yun ;

Yi, Quan ;

Zhang, Genshui ;

He, Lishan ;

Chen, Fajiang ;

Liu, Yingping ;

Luo, Jiandong .

MOLECULAR NEUROBIOLOGY, 2016, 53 (03) :1648-1653

[8] Survivin and Tumorigenesis: Molecular Mechanisms and Therapeutic Strategies [J].

Chen, Xun ;

Duan, Ning ;

Zhang, Caiguo ;

Zhang, Wentao .

JOURNAL OF CANCER, 2016, 7 (03) :314-323

[9]

Chu JS, 2004, J FORMOS MED ASSOC, V103, P925

[10] The role of Survivin as a biomarker and potential prognostic factor for breast cancer [J].

da Veiga, Glaucia Luciano ;

Machado da Silva, Raissa Daniel ;

Pereira, Edimar Cristiano ;

Azzalis, Ligia Ajaime ;

Aguiar Alves, Beatriz da Costa ;

Gehrke, Flovia de Sousa ;

Gascon, Thais Moura ;

Affonso Fonseca, Fernando Luiz .

REVISTA DA ASSOCIACAO MEDICA BRASILEIRA, 2019, 65 (06) :893-901

← 1 2 3 4 5 6 →