Significance of combined TGF-1 and survivin expression on the prognosis of patients with triple-negative breast cancer

被引：7

作者：

Liu, Nannan ^{[1
]}

Qi, Dongxue ^{[2
]}

Jiang, Jing ^{[3
]}

Zhang, Jihong ^{[3
]}

Yu, Chunyan ^{[1
,4
]}

机构：

[1] Beihua Univ, Coll Basic Med, Dept Pathol, Jilin 132013, Peoples R China

[2] Lianyungang First Peoples Hosp, Dept Pathol, Lianyungang 222000, Jiangsu, Peoples R China

[3] Beihua Univ, Dept Pathol, Affiliated Hosp, Jilin 132011, Peoples R China

[4] Beihua Univ, Coll Basic Med, Dept Pathol, 3999 Binjiang East St, Jilin 132013, Peoples R China

来源：

ONCOLOGY LETTERS | 2022年 / 23卷 / 06期

关键词：

TGF-beta; 1; survivin; triple-negative breast cancer; non-triple-negative breast cancer; immunochemistry assay; GROWTH-FACTOR-BETA; EPITHELIAL-MESENCHYMAL TRANSITION; GENE-EXPRESSION; SPLICE-VARIANTS; DOWN-REGULATION; POOR-PROGNOSIS; KAPPA-B; CELLS; TGF-BETA-1; APOPTOSIS;

D O I：

10.3892/ol.2022.13313

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Compared with other types of breast cancer, triple-negative breast cancer (TNBC) has the characteristics of rapid progression, a lack of specific molecular targets for treatment and a poor prognosis. However, based on previously published studies, TGF-beta 1 and survivin are potentially meaningful for the prognosis of patients with TNBC. The present study was therefore designed to measure and compare the expression of transforming growth factor-beta 1 (TGF-beta 1) and survivin in tissue samples of TNBC and non-TNBC patients in order to evaluate their ability as prognostic indicators. In total, 90 TNBC and 52 non-TNBC tissue specimens were selected, following which immunohistochemistry was used to detect the expression of TGF-beta 1 and survivin in the cancer tissues. Subsequently, the potential association between the expression levels of these two proteins and the clinicopathological variables was analyzed. The expression levels of TGF-beta 1 and survivin in TNBC tissues were found to be significantly higher compared with those in the non-TNBC tissues. In addition, the results of the present study demonstrated that TGF-beta 1 expression was positively associated with survivin expression in the TNBC samples, but no significant correlation was found between TGF-beta 1 and survivin expression in the non-TNBC samples. Kaplan-Meier (K-M) analysis was performed to assess the levels of TGF-beta 1 and survivin in regard to patient survival, and univariate and multivariate Cox analyses of TGF-beta 1 and survivin protein expression were performed to analyze the overall survival (OS) and progression-free survival (PFS) rates of patients with TNBC and non-TNBC. Although multivariate Cox analysis demonstrated that neither TGF-beta 1 or survivin were independent prognostic predictors of TNBC or non-TNBC, results of the K-M curve revealed that patients with TNBC with TGF-beta 1- and survivin-positive breast cancer exhibited shorter OS and PFS times. Multivariate Cox analysis demonstrated that in patients with TNBC, the combined expression of TGF-beta 1 and survivin may yield additional prognostic information, compared with patients with non-TNBC.

引用

页数：12

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