The Influence of Implantation of Plasma-Modified Polylactic Acid Films on the Structure of the Cornea

The purpose of this research is the study the influence of the plasma-modified PLA films implantation on the morphology of the cornea in vivo experiment. Studies were performed on 12 pubescent female Sylvilagus bachmani rabbits. Plasma-modified PLA films were implanted into the anterior chamber of one animal eye. The feedstock for the films was obtained by dissolving PLA in the chloroform. Modification of the films was carried out using the low-temperature plasma. Such methods as visual check, photographic registration, non-contact ocular tonometry and optical coherent tomography of cornea were also used in the course of the experiment. Sampling was performed on day 21 after the start of the experiment for morphology studying. Results showed that the implantation of the plasma-modified PLA films contributes to the development of the mild inflammatory response (mild leukocyte infiltration, newly formed blood vessels, increased twisted stroke of collagen fibers, and presence of strongly acid sulfated GAGs) as a result of the surgery. The study showed the possibility of PLA films using as a corneal implant.