Enterovirus 71 meningoencephalitis complicating rituximab therapy

被引：17

作者：

Ahmed, Rebekah ^{[1
]}

Buckland, Michael ^{[2
]}

Davies, Leo ^{[1
]}

Halmagyi, G. Michael ^{[1
]}

Rogers, Shannon L. ^{[3
]}

Oberste, Steven ^{[3
]}

Barnett, Michael H. ^{[1
]}

机构：

[1] Univ Sydney, Royal Prince Alfred Hosp, Inst Clin Neurosci, Sydney, NSW 2006, Australia

[2] Royal Prince Alfred Hosp, Dept Neuropathol, Sydney, NSW, Australia

[3] Ctr Dis Control & Prevent, Atlanta, GA USA

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 2011年 / 305卷 / 1-2期

关键词：

Enterovirus; 71; Encephalitis; Rituximab; Monoclonal antibody; ANTI-CD20; MONOCLONAL-ANTIBODY; DIRECT IDENTIFICATION; AMPLIFICATION; SEROTYPES; LYMPHOMA;

D O I：

10.1016/j.jns.2011.03.009

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We describe a fatal case of proven enterovirus 71 meningoencephalitis complicating monoclonal anti-CD20 antibody therapy for non-Hodgkin's lymphoma. B-cell depletion, an effective treatment strategy in an expanding spectrum of hematological and inflammatory disorders, impairs neutralising antibody-mediated clearance of enterovirus. The global threat of emerging neurotropic viruses such as enterovirus 71 is heightened by an increasing pool of susceptible individuals in non-endemic regions. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：149 / 151

页数：3

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