Safety immunogenicity and protective efficacy in mice of a new cell-cultured Lister smallpox vaccine candidate

被引：16
|
作者：
Ferrier-Rembert, Audrey [4 ]
Drillien, Robert [2 ,3 ]
Meignier, Bernard [1 ]
Garin, Daniel [4 ]
Crance, Jean-Marc [4 ]
机构：
[1] Sanofi Pasteur, Marcy LEtoile, France
[2] INSERM, IGBMC, U596, CNRS,UMR7104, F-67400 Illkirch Graffenstaden, France
[3] Univ Strasbourg, F-67000 Strasbourg, France
[4] CRSSA, Virol Unit, F-38702 Grenoble, France
来源：
VACCINE | 2007年 / 25卷 / 49期
关键词：
mice; smallpox vaccine; vaccinia; cowpox; smallpox; variola; immunogenicity; protection;
D O I：
10.1016/j.vaccine.2007.09.050
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
It is now difficult to manufacture the first-generation smallpox vaccine, as the process could not comply with current safety and manufacturing regulations. In this study, a candidate non-clonal second-generation smallpox vaccine developed by Sanofi-Pasteur from the Lister strain has been assessed using a cowpox virus challenge in mice. We have observed similar safety, immunogenicity and protection (from disease and death) after a short or long interval following vaccination, as well as similar virus clearance post-challenge, with the second-generation smallpox vaccine candidate as compared to the traditional vaccine used as a benchmark. (C) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：8290 / 8297
页数：8
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