Genistein appears to prevent early postmenopausal bone loss as effectively as hormone replacement therapy

被引:50
作者
Cotter, A [1 ]
Cashman, KD
机构
[1] Natl Univ Ireland Univ Coll Cork, Dept Nutr & Food Sci, Cork, Ireland
[2] Natl Univ Ireland Univ Coll Cork, Dept Med, Cork, Ireland
关键词
genistein; phytoestrogens; postmenopausal bone loss; HRT;
D O I
10.1301/nr.2003.oct.346-351
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Recent data from a randomized, double-blind, placebo-controlled, yearlong clinical trial suggest that supplementation with the dietary phytoestrogen genistein (54 mg/day) may be as effective as hormone replacement therapy in attenuating menopause-related bone loss without causing the associated side effects. These findings may have implications for the development of diet-based strategies aimed at osteoporosis prevention.
引用
收藏
页码:346 / 351
页数:6
相关论文
共 22 条
  • [11] Role of estrogens in the management of postmenopausal bone loss
    Gallagher, JC
    [J]. RHEUMATIC DISEASE CLINICS OF NORTH AMERICA, 2001, 27 (01) : 143 - +
  • [12] Dietary soy isoflavones and bone mineral density: Results from the Study of Women's Health Across the Nation
    Greendale, GA
    FitzGerald, G
    Huang, MH
    Sternfeld, B
    Gold, E
    Seeman, T
    Sherman, S
    Sowers, M
    [J]. AMERICAN JOURNAL OF EPIDEMIOLOGY, 2002, 155 (08) : 746 - 754
  • [13] Hsu CS, 2001, J REPROD MED, V46, P221
  • [14] Selective effects of genistein, a soybean isoflavone, on B-lymphopoiesis and bone loss caused by estrogen deficiency
    Ishimi, Y
    Miyaura, C
    Ohmura, M
    Onoe, Y
    Sato, T
    Uchiyama, Y
    Ito, M
    Wang, XX
    Suda, T
    Ikegami, S
    [J]. ENDOCRINOLOGY, 1999, 140 (04) : 1893 - 1900
  • [15] Kiely M, 2003, BRIT J NUTR, V89, pS19, DOI [10.1079/BJN2002731, 10.1079/BJN2002792]
  • [16] Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor β
    Kuiper, GGJM
    Lemmen, JG
    Carlsson, B
    Corton, JC
    Safe, SH
    van der Saag, PT
    van der Burg, P
    Gustafsson, JÄ
    [J]. ENDOCRINOLOGY, 1998, 139 (10) : 4252 - 4263
  • [17] Effects of genistein and hormone-replacement therapy on bone loss in early postmenopausal women: A randomized double-blind placebo-controlled study
    Morabito, N
    Crisafulli, A
    Vergara, C
    Gaudio, A
    Lasco, A
    Frisina, N
    D'Anna, R
    Corrado, F
    Pizzoleo, MA
    Cincotta, M
    Altavilla, D
    Ientile, R
    Squadrito, F
    [J]. JOURNAL OF BONE AND MINERAL RESEARCH, 2002, 17 (10) : 1904 - 1912
  • [18] EFFECTS OF ESTROGEN EXPOSURE AND REPRODUCTIVE FACTORS ON BONE-MINERAL DENSITY AND OSTEOPOROTIC FRACTURES
    NGUYEN, TV
    JONES, G
    SAMBROOK, PN
    WHITE, CP
    KELLY, PJ
    EISMAN, JA
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1995, 80 (09) : 2709 - 2714
  • [19] Soy protein and isoflavones: their effects on blood lipids and bone density in postmenopausal women
    Potter, SM
    Baum, JA
    Teng, HY
    Stillman, RJ
    Shay, NF
    Erdman, JW
    [J]. AMERICAN JOURNAL OF CLINICAL NUTRITION, 1998, 68 (06) : 1375S - 1379S
  • [20] Taylor Maida, 1997, Comprehensive Therapy, V23, P514