Nanofibers of silk fibroin controlled by the crystallization of polyethylene glycol in frozen solution

被引：1
|
作者：
Chen, Cong-heng [1 ]
Zhao, Juan [1 ]
Yang, Zhou [1 ]
Sun, Qing [1 ]
Zhou, Ping [1 ]
机构：
[1] Fudan Univ, Dept Macromol Sci, State Key Lab Mol Engn Polymers, Shanghai 200433, Peoples R China
来源：
CHINESE JOURNAL OF POLYMER SCIENCE | 2017年 / 35卷 / 11期
基金：
中国国家自然科学基金;
关键词：
Silk fibroin; Polyethylene glycol; Freezing; Phase separation; Crystallization; CONFORMATION TRANSITION KINETICS; FREEZING METHODS; DRUG-DELIVERY; PROTEIN; PEGYLATION; STABILITY; NANOPARTICLES; POLYMER;
D O I：
10.1007/s10118-017-1974-x
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
The conformation of silk fibroin (SF) frozen with polyethylene glycol (PEG) at a molecular weight from 2 kDa to 20 kDa and a mass ratio of PEG:SF from 1:5 to 10:1 was studied by spectral and microscopic methods. It is found that the conformation transition of SF from random coil to beta-sheet could be induced by the stress resulting from PEG crystallization at -20 A degrees C, and greatly depended on the cooling rate, PEG:SF mass ratio and PEG molecular weight. These findings provide a new method for the preparation of desired SF nanofibers.
引用
收藏
页码：1373 / 1380
页数：8
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