Amine functionalised hydroxyapatite nanoparticles for anti-angiogenesis gene therapy of breast cancer

被引：10

作者：

Xu, Hongjie ^{[1
]}

Wei, Dajun ^{[2
]}

Gai, Xiaodong ^{[3
]}

Jiang, Ying ^{[4
]}

机构：

[1] Beihua Univ, Dept Oncol, Affiliated Hosp, 12 Jiefang Middle Rd, Jilin 132011, Jilin Province, Peoples R China

[2] Beihua Univ, Dept Cardiol, Affiliated Hosp, 12 Jiefang Middle Rd, Jilin 132011, Jilin Province, Peoples R China

[3] Beihua Univ, Sch Basic Med Sci, 3999 Binjiang East Rd, Jilin 132011, Jilin Province, Peoples R China

[4] Hlth Serv Ctr Wenmiao Community, Jilin 132011, Jilin Province, Peoples R China

来源：

MICRO & NANO LETTERS | 2016年 / 11卷 / 08期

关键词：

nanoparticles; nanomedicine; cancer; sodium compounds; gene therapy; cellular biophysics; drug delivery systems; amine functionalised hydroxyapatite nanoparticles; antiangiogenesis gene therapy; functionalised hydroxyapatite nanoparticle-based drug delivery system; antiangiogenesis-amine functionalised HAP nanoparticles; therapeutic ANG plasmid; plasmid condensation; cellular assays; MCF-7; cells; ANG-NHAP nanoparticle low-cytotoxicity; breast cancer gene therapy; Ca-10(PO4)(6)(OH)(2); ENDOTHELIAL GROWTH-FACTOR; TARGETED CO-DELIVERY; IN-VITRO; CELLS; DRUG; POLYETHYLENEIMINE; EXPRESSION; RECEPTOR; VIVO;

D O I：

10.1049/mnl.2016.0078

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

A functionalised hydroxyapatite (HAP) nanoparticles based drug delivery system (DDS) [anti-angiogenesis (ANG)/amine functionalised HAP (NHAP) nanoparticles] composed of HAP nanoparticles and therapeutic ANG plasmid was successfully developed for gene therapy of breast cancer. ANG/NHAP nanoparticles displayed nano-sized diameter of around 50 nm and effective plasmid condensation ability. Cellular assays on MCF-7 cells further confirmed high transfection and ANG efficacy as well as low cytotoxicity of ANG/NHAP nanoparticles, which suggested that ANG/NHAP nanoparticles might be a safe and effective DDS for potential breast cancer gene therapy.

引用

页码：416 / 419

页数：4

共 18 条

[1] Amaya K, 2004, INT J ONCOL, V25, P849
[2] Angiotensin II induces vascular endothelial growth factor in pancreatic cancer cells through an angiotensin II type 1 receptor and ERK1/2 signaling
Anandanadesan, Rathai
Gong, Qiaoke
Chipitsyna, Galina
Witkiewicz, Agnes
Yeo, Charles J.
Arafat, Hwyda A.
[J]. JOURNAL OF GASTROINTESTINAL SURGERY, 2008, 12 (01) : 57 - 66
[3] A chitosan-graft-PEI-candesartan conjugate for targeted co-delivery of drug and gene in anti-angiogenesis cancer therapy
Bao, Xiuli
Wang, Wei
Wang, Cheng
Wang, Yu
Zhou, Jianping
Ding, Yang
Wang, Xiaoyi
Jin, Yuting
[J]. BIOMATERIALS, 2014, 35 (29) : 8450 - 8466
[4] Bharali DJ, 2005, P NATL ACAD SCI USA, V102, P11539, DOI 10.1073/pnas.0504926102
[5] Chen QR, 1999, CANCER RES, V59, P3308
[6] ANTI-ANGIOGENESIS - NEW CONCEPT FOR THERAPY OF SOLID TUMORS
FOLKMAN, J
[J]. ANNALS OF SURGERY, 1972, 175 (03) : 409 - &
[7] Candesartan-graft-polyethyleneimine Cationic Micelles for Effective Co-delivery of Drug and Gene in Anti-angiogenic Lung Cancer Therapy
Hao, Shanhu
Yan, Ying
Ren, Xue
Xu, Ying
Chen, Lanlan
Zhang, Haibo
[J]. BIOTECHNOLOGY AND BIOPROCESS ENGINEERING, 2015, 20 (03) : 550 - 560
[8] The in vivo performance of biomagnetic hydroxyapatite nanoparticles in cancer hyperthermia therapy
Hou, Chun-Han
Hou, Sheng-Mou
Hsueh, Yu-Sheng
Lin, Jinn
Wu, Hsi-Chin
Lin, Feng-Huei
[J]. BIOMATERIALS, 2009, 30 (23-24) : 3956 - 3960
[9] Poly(lactide-co-glycolide)/hydroxyapatite delivery of BMP-2-producing cells: a regional gene therapy approach to bone regeneration
Laurencin, CT
Attawia, MA
Lu, LQ
Borden, MD
Lu, HH
Gorum, WJ
Lieberman, JR
[J]. BIOMATERIALS, 2001, 22 (11) : 1271 - 1277
[10] Molecular weight-dependent gene transfection activity of unmodified and galactosylated polyethyleneimine on hepatoma cells and mouse liver
Morimoto, K
Nishikawa, M
Kawakami, S
Nakano, T
Hattori, Y
Fumoto, S
Yamashita, F
Hashida, M
[J]. MOLECULAR THERAPY, 2003, 7 (02) : 254 - 261

← 1 2 →