Selection of solubility parameters for characterization of pharmaceutical excipients

被引:39
作者
Adamska, Katarzyna
Voelkel, Adam
Heberger, Karoly
机构
[1] Poznan Tech Univ, Inst Chem Technol & Engn, PL-60965 Poznan, Poland
[2] Hungarian Acad Sci, Chem Res Ctr, H-1025 Budapest, Hungary
关键词
principal component analysis; inverse gas chromatography; hansen solubility parameters; chemometrics;
D O I
10.1016/j.chroma.2007.09.034
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
The solubility parameter (delta(2)), corrected solubility parameter (delta(T)) and its components (delta(d), delta(p), delta(h)) were determined for series of pharmaceutical excipients by using inverse gas chromatography (IGC). Principal component analysis (PCA) was applied for the selection of the solubility parameters which assure the complete characterization of examined materials. Application of PCA suggests that complete description of examined materials is achieved with four solubility parameters, i.e. delta(2) and Hansen solubility parameters (delta(d), delta(p), delta(h)) Selection of the excipients through PCA of their solubility parameters data can be used for prediction of their behavior in a multi-component system, e.g. for selection of the best materials to form stable pharmaceutical liquid mixtures or stable coating formulation. (c) 2007 Elsevier B.V. All rights reserved.
引用
收藏
页码:90 / 97
页数:8
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