Methods for the determination of neutral drugs as well as betablockers and β2-sympathomimetics in aqueous matrices using GC/MS and LC/MS/MS

被引:135
作者
Ternes, TA [1 ]
Hirsch, R [1 ]
Mueller, J [1 ]
Haberer, K [1 ]
机构
[1] ESWE, Inst Water Res & Water Technol, D-65201 Wiesbaden, Germany
来源
FRESENIUS JOURNAL OF ANALYTICAL CHEMISTRY | 1998年 / 362卷 / 03期
关键词
D O I
10.1007/s002160051083
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
An analytical method has been developed which allows the determination of 22 different neutral and weakly basic drugs belonging to several different medicinal classes like antiphlogistics, betablockers, beta(2)-sympathomimetics, lipid regulators, antiepileptic agents, psychiatric drugs and vasodilators in waste water as well as in river and drinking water. A method including solid phase extraction, derivatization by silylation and detection by GC/MS permits detection down to 5 ng/L. The recovery rates mostly exceeded 70%. However, the determination of phenazone, carbamazepine, cyclophosphamide, ifosfamide and pentoxiphylline is frequently disturbed by organic co-extractants in real samples of rivers and waste waters. Therefore, a time saving alternative method has been developed, combining solid phase extraction (as an enrichment step) together with detection by LC-electrospray/MS/MS allowing the measurement of 5 neutral drugs. Detection limits down to 10 ng/L have been achieved even for organically highly contaminated waters like sewage treatment plant effluents.
引用
收藏
页码:329 / 340
页数:12
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