Manganese oxide increases bleaching efficacy and reduces the cytotoxicity of a 10% hydrogen peroxide bleaching gel

被引:13
作者
de Oliveira Ribeiro, Rafael Antonio [1 ]
Zuta, Uxua Ortecho [1 ]
Mendes Soares, Igor Paulino [1 ]
Anselmi, Caroline [2 ]
Soares, Diana Gabriela [3 ]
Fraga Briso, Andre Luiz [4 ]
Hebling, Josimeri [2 ]
de Souza Costa, Carlos Alberto [5 ]
机构
[1] Sao Paulo State Univ, Sch Dent, Dept Dent Mat & Prosthodont, UNESP, Araraquara, SP, Brazil
[2] Sao Paulo State Univ, Sch Dent, Dept Morphol & Pediat Dent, UNESP, Araraquara, SP, Brazil
[3] Sao Paulo Univ USP, Sch Dent, Dept Dent Endodont & Dent Mat, Bauru, SP, Brazil
[4] Sao Paulo State Univ, Sch Dent, Dept Restorat Dent, UNESP, Aracatuba, Brazil
[5] Sao Paulo State Univ, Sch Dent, Dept Physiol & Pathol, UNESP, Araraquara, SP, Brazil
基金
巴西圣保罗研究基金会;
关键词
Tooth bleaching; Dental materials; Cell culture; Toxicity; TOOTH SENSITIVITY; PULP; RESPONSES;
D O I
10.1007/s00784-022-04688-3
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
Objective The study aims to assess the effects of a 10% H2O2 bleaching gel with different MnO2 concentrations on the bleaching efficacy (BE), degradation kinetics (DK) of H2O2, and trans-amelodentinal cytotoxicity (TC). Materials and methods Standardized bovine enamel/dentin disks (n = 96) were placed in artificial pulp chambers, and the bleaching gels were applied for 45 min. Thus, the following groups were established: (G1) no treatment (negative control/NC); (G2) 35% H2O2 (positive control/PC); (G3) 10% H2O2; (G4) 10% H2O2 + 2 mg/mL MnO2; (G5) 10% H2O2 + 6 mg/mL MnO2; and (G6) 10% H2O2 + 10 mg/mL MnO2. After analyzing bleaching efficacy (Delta E-00 and Delta WI), the degradation kinetics of H2O2 and trans-amelodentinal cytotoxicity were determined (n = 8, ANOVA/Tukey; p < 0.05). Results G6 presented BE (Delta E-00 and Delta WI) statistically similar to G2, which represented conventional in-office bleaching (p = 0.6795; p > 0.9999). A significant reduction in the diffusion of H2O2 occurred in G3, G4, G5, and G6 compared to G2 (p < 0.0001). The highest DK of H2O2 occurred in G6 (p < 0.0001), which had the lowest TC in comparison with all other bleached groups (p <= 0.0186). Conclusion The addition of 10 mg/mL of MnO2 in a 10% H2O2 bleaching gel potentiates the degradation of this reactive molecule, which increases the BE of the product and decreases TC. Clinical significance Replacing a 35% H2O2 gel commonly used for conventional in-office dental bleaching by a 10% H2O2 gel containing 10 mg/mL of MnO2 reduces the cytotoxicity of this professional therapy, maintaining its excellent esthetic efficacy.
引用
收藏
页码:7277 / 7286
页数:10
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