Xishaglaucumins A-J, New Cembranoids with Anti-Inflammatory Activities from the South China Sea Soft Coral Sarcophyton glaucum

被引：13

作者：

Li, Jin-Feng ^{[1
,2
,3
]}

Zeng, Yan-Bo ^{[1
,3
]}

Li, Wang-Sheng ^{[2
,4
]}

Luo, Hui ^{[4
]}

Zhang, Hai-Yan ^{[2
]}

Guo, Yue-Wei ^{[2
,5
]}

机构：

[1] Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Hainan Prov Key Lab Funct Components Res & Utiliz, Haikou 571101, Hainan, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China

[3] Hebei Agr Univ, Ocean Coll, Qinhuangdao 066000, Hebei, Peoples R China

[4] Guangdong Med Univ, Marine Biomed Res Inst, Key Lab Zhanjiang Res & Dev Marine Microbial Reso, Zhanjiang 524023, Guangdong, Peoples R China

[5] Bohai Rim Adv Res Inst Drug Discovery, Yantai 264000, Shandong, Peoples R China

来源：

CHINESE JOURNAL OF CHEMISTRY | 2022年 / 40卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Sarcophyton glaucum; Cembranoids; Configuration determination; X-ray diffraction; NMR spectroscopy; ANTI-TUMOR-PROMOTER; MARINE TERPENES; METABOLITES; DITERPENES; CHEMISTRY;

D O I：

10.1002/cjoc.202100564

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Ten new cembrane-type diterpenoids, namely xishaglaucumins A-J (1-10), along with ten known related ones (11-20), have been isolated from the soft coral Sarcophyton glaucum collected off the Xisha Island in the South China Sea. Their structures were elucidated by extensive spectroscopic analysis, quantum mechanical nuclear magnetic resonance (QM-NMR) methods, X-ray diffraction analysis, chemical methods and comparison with the reported data in the literature. The absolute configuration of new compounds 1, 5 and known compounds 11, 12, 16 and 20 were determined either by chemical methods or by X-ray diffraction analysis using Cu K alpha (lambda = 1.5417 angstrom). In in vitro bioassay, compound 4 exhibited inhibitory effects on lipopolysaccharide (LPS)-induced inflammatory responses in BV-2 microglial cells. [GRAPHICS]

引用

页码：79 / 90

页数：12

共 40 条

[1] STUDIES OF AUSTRALIAN SOFT CORALS .24. 2 CEMBRANOID DITERPENES FROM THE SOFT CORAL SINULARIA-FACILE [J].