Preoperative prognostic nutritional index and systemic immune-inflammation index predict survival outcomes in osteosarcoma: A comparison between young and elderly patients
被引:14
作者:
Ma, Cong
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机构:
Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Orthopaed, Wuhan, Hubei, Peoples R China
Huazhong Univ Sci & Technol, Liyuan Hosp, Tongji Med Coll, Dept Orthopaed, Wuhan 430077, Hubei, Peoples R ChinaHuazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Orthopaed, Wuhan, Hubei, Peoples R China
Ma, Cong
[1
,2
]
Yu, Ronghui
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机构:
Nanchang Univ, Dept Orthopaed, Affiliated Hosp 1, Nanchang, Jiangxi, Peoples R ChinaHuazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Orthopaed, Wuhan, Hubei, Peoples R China
Yu, Ronghui
[3
]
Li, Junhong
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机构:
Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Orthopaed, Wuhan, Hubei, Peoples R ChinaHuazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Orthopaed, Wuhan, Hubei, Peoples R China
Li, Junhong
[1
]
Guo, Jingjing
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机构:
Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Hematol, Wuhan, Hubei, Peoples R ChinaHuazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Orthopaed, Wuhan, Hubei, Peoples R China
Guo, Jingjing
[4
]
Xu, Jianyun
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机构:
Nanchang Univ, Dept Orthopaed, Affiliated Hosp 1, Nanchang, Jiangxi, Peoples R ChinaHuazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Orthopaed, Wuhan, Hubei, Peoples R China
Xu, Jianyun
[3
]
Wang, Xiaoyan
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机构:
Nanchang Univ, Dept Orthopaed, Affiliated Hosp 1, Nanchang, Jiangxi, Peoples R ChinaHuazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Orthopaed, Wuhan, Hubei, Peoples R China
Wang, Xiaoyan
[3
]
Liu, Ping
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Huazhong Univ Sci & Technol, Liyuan Hosp, Tongji Med Coll, Dept Orthopaed, Wuhan 430077, Hubei, Peoples R ChinaHuazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Orthopaed, Wuhan, Hubei, Peoples R China
Liu, Ping
[2
]
机构:
[1] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Orthopaed, Wuhan, Hubei, Peoples R China
[2] Huazhong Univ Sci & Technol, Liyuan Hosp, Tongji Med Coll, Dept Orthopaed, Wuhan 430077, Hubei, Peoples R China
[3] Nanchang Univ, Dept Orthopaed, Affiliated Hosp 1, Nanchang, Jiangxi, Peoples R China
[4] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Hematol, Wuhan, Hubei, Peoples R China
osteosarcoma;
prognosis;
prognostic nutritional index;
systemic immune-inflammation index;
young and elderly;
LYMPHOCYTE RATIO NLR;
SERUM-ALBUMIN;
CANCER;
LUNG;
ANGIOGENESIS;
NEUTROPHILS;
MECHANISMS;
CELLS;
DIET;
BONE;
D O I:
10.1002/jso.26757
中图分类号:
R73 [肿瘤学];
学科分类号:
100214 ;
摘要:
Objective This retrospective study of patients with osteosarcoma investigated the following biomarkers of inflammation and nutritional status: neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, prognostic nutritional index (PNI), and systemic immune-inflammation index (SII). The efficacies of these indicators to predict overall survival (OS) of young and elderly patients were compared. Methods The data of 125 patients with osteosarcoma, comprising the young (<= 20 years) and elderly (60-80 years), were reviewed. Receiver operating characteristic (ROC) curves were calculated to determine the optimal cut-off value and area under the ROC curve of each potential biomarker. Kaplan-Meier curves and a Cox proportional hazards model were used to perform survival analyses. Results The cut-off values for low and high PNI ( <= 48.5, >48.5) and low and high SII (<= 607.3, >607.3) were determined. Osteosarcoma patients in low PNI group or high SII group exhibited poorer OS relative to those in high PNI or low SII groups. The univariate and multivariate analyses indicated that preoperative PNI and SII were independent prognostic factors for OS in both the young and elderly subjects. Conclusion Preoperative PNI and SII can be viable biomarkers of prognosis for both young and elderly patients with osteosarcoma. Awareness of these valuable indexes will enable clinicians to evaluate the inflammatory and nutritional status of these patients and establish a framework for individualized therapy.
机构:
Univ Sydney, Royal N Shore Hosp, Kolling Inst Med Res, Sydney, NSW 2006, AustraliaUniv Sydney, Royal N Shore Hosp, Kolling Inst Med Res, Sydney, NSW 2006, Australia
Diakos, Connie I.
Charles, Kellie A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sydney, Sydney Med Sch, Sydney, NSW 2006, AustraliaUniv Sydney, Royal N Shore Hosp, Kolling Inst Med Res, Sydney, NSW 2006, Australia
Charles, Kellie A.
McMillan, Donald C.
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机构:
Univ Glasgow, Royal Infirm, Sch Med, Acad Surg Unit, Glasgow, Lanark, ScotlandUniv Sydney, Royal N Shore Hosp, Kolling Inst Med Res, Sydney, NSW 2006, Australia
McMillan, Donald C.
Clarke, Stephen J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sydney, Royal N Shore Hosp, Kolling Inst Med Res, Sydney, NSW 2006, AustraliaUniv Sydney, Royal N Shore Hosp, Kolling Inst Med Res, Sydney, NSW 2006, Australia
机构:
Yale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06520 USA
Yale Univ, Sch Med, Dept Mol Biophys & Biochem, New Haven, CT 06520 USAWeizmann Inst Sci, Dept Immunol, IL-76100 Rehovot, Israel
Hu, Bo
Jin, Chengcheng
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机构:
Yale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06520 USA
Yale Univ, Sch Med, Dept Cell Biol, New Haven, CT 06520 USAWeizmann Inst Sci, Dept Immunol, IL-76100 Rehovot, Israel
Jin, Chengcheng
Flavell, Richard A.
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机构:
Yale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06520 USA
Howard Hughes Med Inst, New Haven, CT 06520 USAWeizmann Inst Sci, Dept Immunol, IL-76100 Rehovot, Israel
机构:
Univ Calif San Diego, Sch Med, Dept Pharmacol, Lab Gene Regulat & Signal Transduct, La Jolla, CA 92093 USA
Univ Calif San Diego, Sch Med, Dept Pathol, Lab Gene Regulat & Signal Transduct, La Jolla, CA 92093 USAUniv Calif San Diego, Sch Med, Dept Pharmacol, Lab Gene Regulat & Signal Transduct, La Jolla, CA 92093 USA
Grivennikov, Sergei I.
Greten, Florian R.
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h-index: 0
机构:
Tech Univ Munich, Klinikum Rechts Isar, Dept Med 2, D-81675 Munich, GermanyUniv Calif San Diego, Sch Med, Dept Pharmacol, Lab Gene Regulat & Signal Transduct, La Jolla, CA 92093 USA
Greten, Florian R.
Karin, Michael
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Sch Med, Dept Pharmacol, Lab Gene Regulat & Signal Transduct, La Jolla, CA 92093 USA
Univ Calif San Diego, Sch Med, Dept Pathol, Lab Gene Regulat & Signal Transduct, La Jolla, CA 92093 USAUniv Calif San Diego, Sch Med, Dept Pharmacol, Lab Gene Regulat & Signal Transduct, La Jolla, CA 92093 USA
机构:
Univ Sydney, Royal N Shore Hosp, Kolling Inst Med Res, Sydney, NSW 2006, AustraliaUniv Sydney, Royal N Shore Hosp, Kolling Inst Med Res, Sydney, NSW 2006, Australia
Diakos, Connie I.
Charles, Kellie A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sydney, Sydney Med Sch, Sydney, NSW 2006, AustraliaUniv Sydney, Royal N Shore Hosp, Kolling Inst Med Res, Sydney, NSW 2006, Australia
Charles, Kellie A.
McMillan, Donald C.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Glasgow, Royal Infirm, Sch Med, Acad Surg Unit, Glasgow, Lanark, ScotlandUniv Sydney, Royal N Shore Hosp, Kolling Inst Med Res, Sydney, NSW 2006, Australia
McMillan, Donald C.
Clarke, Stephen J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sydney, Royal N Shore Hosp, Kolling Inst Med Res, Sydney, NSW 2006, AustraliaUniv Sydney, Royal N Shore Hosp, Kolling Inst Med Res, Sydney, NSW 2006, Australia
机构:
Yale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06520 USA
Yale Univ, Sch Med, Dept Mol Biophys & Biochem, New Haven, CT 06520 USAWeizmann Inst Sci, Dept Immunol, IL-76100 Rehovot, Israel
Hu, Bo
Jin, Chengcheng
论文数: 0引用数: 0
h-index: 0
机构:
Yale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06520 USA
Yale Univ, Sch Med, Dept Cell Biol, New Haven, CT 06520 USAWeizmann Inst Sci, Dept Immunol, IL-76100 Rehovot, Israel
Jin, Chengcheng
Flavell, Richard A.
论文数: 0引用数: 0
h-index: 0
机构:
Yale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06520 USA
Howard Hughes Med Inst, New Haven, CT 06520 USAWeizmann Inst Sci, Dept Immunol, IL-76100 Rehovot, Israel
机构:
Univ Calif San Diego, Sch Med, Dept Pharmacol, Lab Gene Regulat & Signal Transduct, La Jolla, CA 92093 USA
Univ Calif San Diego, Sch Med, Dept Pathol, Lab Gene Regulat & Signal Transduct, La Jolla, CA 92093 USAUniv Calif San Diego, Sch Med, Dept Pharmacol, Lab Gene Regulat & Signal Transduct, La Jolla, CA 92093 USA
Grivennikov, Sergei I.
Greten, Florian R.
论文数: 0引用数: 0
h-index: 0
机构:
Tech Univ Munich, Klinikum Rechts Isar, Dept Med 2, D-81675 Munich, GermanyUniv Calif San Diego, Sch Med, Dept Pharmacol, Lab Gene Regulat & Signal Transduct, La Jolla, CA 92093 USA
Greten, Florian R.
Karin, Michael
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Sch Med, Dept Pharmacol, Lab Gene Regulat & Signal Transduct, La Jolla, CA 92093 USA
Univ Calif San Diego, Sch Med, Dept Pathol, Lab Gene Regulat & Signal Transduct, La Jolla, CA 92093 USAUniv Calif San Diego, Sch Med, Dept Pharmacol, Lab Gene Regulat & Signal Transduct, La Jolla, CA 92093 USA