Next Generation of Androgen Deprivation Therapy Combined With Radiotherapy for N0 M0 Prostate Cancer

被引：1

作者：

Barata, Pedro ^{[1
,2
]}

Layton, Jodi ^{[1
]}

Lewis, Brian ^{[1
]}

Sartor, Oliver ^{[1
,2
]}

机构：

[1] Tulane Univ, Sch Med, Dept Hematol & Med Oncol, 150 S Liberty St, New Orleans, LA 70112 USA

[2] Tulane Univ, Sch Med, Tulane Canc Ctr, 1430 Tulane Ave, New Orleans, LA 70112 USA

来源：

CANCER JOURNAL | 2020年 / 26卷 / 01期

关键词：

androgen synthesis inhibitors; novel hormonal therapies; prostate cancer; radiation therapy; RADIATION-THERAPY; PHASE-III; DEFINITIVE RADIOTHERAPY; EXTERNAL IRRADIATION; IONIZING-RADIATION; INCREASED SURVIVAL; ORTERONEL TAK-700; GENE-EXPRESSION; DNA-REPAIR; OPEN-LABEL;

D O I：

10.1097/PPO.0000000000000428

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Androgen deprivation therapy in combination with definitive radiation therapy is a standard of care for both intermediate-/high-risk localized prostate, locally advanced prostate cancer. Newer hormonal therapies have shown promising results in patients with castration-resistant disease and are now being investigated in early stages, in combination with radiation therapy. In this section, we review the body of evidence elucidating the mechanism of synergy and immune modulation effect of androgen deprivation therapy and radiation therapy, summarize the pivotal studies supporting its use in the nonmetastatic setting, and present the ongoing studies who will likely shape the management of locally advanced disease, in the upcoming years.

引用

页码：21 / 28

页数：8

共 82 条

[1] The phoenix definition of biochemical failure predicts for overall survival in patients with prostate cancer [J].

Abramowitz, Matthew C. ;

Li, Tiaynu ;

Buyyounouski, Mark K. ;

Ross, Eric ;

Uzzo, Robert G. ;

Pollack, Alan ;

Horwitz, Eric M. .

CANCER, 2008, 112 (01) :55-60

[2]

[Anonymous], J CLIN ONCOL S

[3]

Beer TM, 2014, NEW ENGL J MED, V371, P424, DOI 10.1056/NEJMoa1405095

[4] BLOOD LYMPHOCYTES AFTER RADIATION-THERAPY OF MAMMARY-CARCINOMA [J].

BLOMGREN, H ;

GLAS, U ;

MELEN, B ;

WASSERMAN, J .

ACTA RADIOLOGICA-THERAPY PHYSICS BIOLOGY, 1974, 13 (03) :185-200

[5] Improved survival in patients with locally advanced prostate cancer treated with radiotherapy and goserelin [J].

Bolla, M ;

Gonzalez, D ;

Warde, P ;

Dubois, JB ;

Mirimanoff, RO ;

Storme, G ;

Bernier, J ;

Kuten, A ;

Sternberg, C ;

Gil, T ;

Collette, L ;

Pierart, M .

NEW ENGLAND JOURNAL OF MEDICINE, 1997, 337 (05) :295-300

[6] Long-term results with immediate androgen suppression and external irradiation in patients with locally advanced prostate cancer (an EORTC study): a phase III randomised trial [J].

Bolla, M ;

Collette, L ;

Blank, L ;

Warde, P ;

Dubois, JB ;

Mirimanoff, RO ;

Storme, G ;

Bernier, J ;

Kuten, A ;

Sternberg, C ;

Mattelaer, J ;

Torecilla, JL ;

Pfeffer, JR ;

Cutajar, CL ;

Zurlo, A ;

Pierart, M .

LANCET, 2002, 360 (9327) :103-108

[7] Short Androgen Suppression and Radiation Dose Escalation for Intermediate- and High-Risk Localized Prostate Cancer: Results of EORTC Trial 22991 [J].

Bolla, Michel ;

Maingon, Philippe ;

Carrie, Christian ;

Villa, Salvador ;

Kitsios, Petros ;

Poortmans, Philip M. P. ;

Sundar, Santhanam ;

van der Steen-Banasik, Elzbieta M. ;

Armstrong, John ;

Bosset, Jean-Francois ;

Herrera, Fernanda G. ;

Pieters, Bradley ;

Slot, Annerie ;

Bahl, Amit ;

Ben-Yosef, Rahamim ;

Boehmer, Dirk ;

Scrase, Christopher ;

Renard, Laurette ;

Shash, Emad ;

Coens, Corneel ;

van den Bergh, Alphonsus C. M. ;

Collette, Laurence .

JOURNAL OF CLINICAL ONCOLOGY, 2016, 34 (15) :1748-+

[8] External irradiation with or without long-term androgen suppression for prostate cancer with high metastatic risk: 10-year results of an EORTC randomised study [J].

Bolla, Michel ;

Van Tienhoven, Geertjan ;

Warde, Padraig ;

Dubois, Jean Bernard ;

Mirimanoff, Rene-Olivier ;

Storme, Guy ;

Bernier, Jacques ;

Kuten, Abraham ;

Sternberg, Cora ;

Billiet, Ignace ;

Lopez Torecilla, Jose ;

Pfeffer, Raphael ;

Cutajar, Carmel Lino ;

Van der Kwast, Theodore ;

Collette, Laurence .

LANCET ONCOLOGY, 2010, 11 (11) :1066-1073

[9] Duration of Androgen Suppression in the Treatment of Prostate Cancer [J].

Bolla, Michel ;

de Reijke, Theodorus M. ;

Van Tienhoven, Geertjan ;

Van den Bergh, Alphonsus C. M. ;

Oddens, Jorg ;

Poortmans, Philip M. P. ;

Gez, Eliahu ;

Kil, Paul ;

Akdas, Atif ;

Soete, Guy ;

Kariakine, Oleg ;

Van der Steen-Banasik, Elsbietha M. ;

Musat, Elena ;

Pierart, Marianne ;

Mauer, Murielle E. ;

Collette, Laurence .

NEW ENGLAND JOURNAL OF MEDICINE, 2009, 360 (24) :2516-2527

[10] Treatment-related Lymphopenia in Patients With Stage III Non-Small-Cell Lung Cancer [J].

Campian, Jian L. ;

Ye, Xiaobu ;

Brock, Malcolm ;

Grossman, Stuart A. .

CANCER INVESTIGATION, 2013, 31 (03) :183-188

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