Role of Transforming Growth Factor-β in Inflammatory Bowel Disease and Colitis-associated Colon Cancer

被引：78
作者：
Feagins, Linda A. [1 ,2 ,3 ]
机构：
[1] VA N Texas Hlth Care Syst, Div Gastroenterol, Dallas, TX USA
[2] VA N Texas Hlth Care Syst, Div Hepatol, Dallas, TX USA
[3] Univ Texas SW Med Ctr Dallas, Dallas, TX 75390 USA
来源：
INFLAMMATORY BOWEL DISEASES | 2010年 / 16卷 / 11期
关键词：
transforming growth factor-beta; cancer risk; carcinogenesis; inflammatory bowel disease; chronic inflammation; TGF-BETA; ULCERATIVE-COLITIS; COLORECTAL-CANCER; TARGETED DISRUPTION; RISK-FACTOR; GROWTH-FACTOR-BETA-1; CELLS; PREVENTION; GENE; PROGRESSION;
D O I：
10.1002/ibd.21281
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Transforming growth factor-beta (TGF-beta) plays a central role in a wide array of cellular functions including control of cell growth and differentiation, embryonic development, wound healing, angiogenesis, and immune regulation. In the gastrointestinal tract. TGF-beta can either promote or suppress inflammation and cancer formation. This report reviews recent data on the role of TGF-beta in the pathogenesis of inflammatory bowel disease and how TGF-beta might contribute to the cancer risk associated with chronic inflammation of the gut.
引用
收藏
页码：1963 / 1968
页数：6
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