The Association of Metabolic Syndrome with Executive Dysfunction Independent of Subclinical Ischemic Brain Lesions in Japanese Adults

被引：34

作者：

Bokura, Hirokazu ^{[1
]}

Nagai, Atsushi ^{[2
]}

Oguro, Hiroaki ^{[1
]}

Kobayashi, Shotai ^{[3
]}

Yamaguchi, Shuhei ^{[1
]}

机构：

[1] Shimane Univ, Fac Med, Dept Neurol, Izumo, Shimane 6938501, Japan

[2] Shimane Univ, Fac Med, Dept Lab Med, Izumo, Shimane 6938501, Japan

[3] Shimane Univ Hosp, Izumo, Shimane, Japan

来源：

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS | 2010年 / 30卷 / 06期

关键词：

Metabolic syndrome; Cognitive impairment; Executive function; Brain lesions; Glucose metabolism; FRONTAL ASSESSMENT BATTERY; WHITE-MATTER CHANGES; MIDDLE-AGED MEN; ALZHEIMERS-DISEASE; COGNITIVE IMPAIRMENT; INSULIN-RESISTANCE; VASCULAR DEMENTIA; RISK-FACTORS; DIABETES-MELLITUS; BLOOD-PRESSURE;

D O I：

10.1159/000322057

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Background/Aims: The aim of this study is to examine whether metabolic syndrome is directly associated with cognitive impairment independent of subclinical ischemic brain lesions. Methods: We examined 1,543 neurologically normal subjects (44-86 years of age). Metabolic syndrome, brain MRI, and cognitive functions including general cognition and executive function were assessed. Results: After adjusting for silent brain lesions and demographic risk factors, metabolic syndrome was an independent risk factor for impairment of executive function (OR = 1.41, 95% CI = 1.17-1.25 for Kohs' Test; OR = 2.25, 95% CI = 1.64-3.07 for Frontal Assessment Battery). Among the components of metabolic syndrome, elevated fasting glucose was the only independent risk factor for impairment of executive function. Conclusion: Metabolic syndrome is associated with impairment of executive function independent of silent brain lesions in the Japanese population. Copyright (C) 2011 S. Karger AG, Basel

引用

页码：479 / 485

页数：7

共 50 条

[41] Association of Metabolic Syndrome with Serum Adipokines in Community-Living Elderly Japanese Women: Independent Association with Plasminogen Activator-Inhibitor-1 [J].

Takeuchi, Mika ;

Tsuboi, Ayaka ;

Kurata, Miki ;

Fukuo, Keisuke ;

Kazumi, Tsutomu .

METABOLIC SYNDROME AND RELATED DISORDERS, 2015, 13 (09) :415-421

[42] Metabolic syndrome, endothelial dysfunction, and erectile dysfunction: Association and management [J].

Burnett A.L. .

Current Urology Reports, 2005, 6 (6) :470-475

[43] Association of metabolic syndrome and electrocardiographic markers of subclinical cardiovascular disease [J].

Theodora W. Elffers ;

Renée de Mutsert ;

Hildo J. Lamb ;

Arie C. Maan ;

Peter W. Macfarlane ;

Ko Willems van Dijk ;

Frits R. Rosendaal ;

J. Wouter Jukema ;

Stella Trompet .

Diabetology & Metabolic Syndrome, 9

[44] Executive dysfunction assessed by Clock-Drawing Test in older non-demented subjects with metabolic syndrome is not mediated by white matter lesions [J].

Viscogliosi, Giovanni ;

Chiriac, Iulia Maria ;

Andreozzi, Paola ;

Ettorre, Evaristo .

PSYCHIATRY AND CLINICAL NEUROSCIENCES, 2015, 69 (10) :620-629

[45] Association of metabolic syndrome and electrocardiographic markers of subclinical cardiovascular disease [J].

Elffers, Theodora W. ;

de Mutsert, Renee ;

Lamb, Hildo J. ;

Maan, Arie C. ;

Macfarlane, Peter W. ;

van Dijk, Ko Willems ;

Rosendaal, Frits R. ;

Jukema, J. Wouter ;

Trompet, Stella .

DIABETOLOGY & METABOLIC SYNDROME, 2017, 9

[46] Subclinical Vascular Dysfunction Associated with Metabolic Syndrome in African Americans and Whites [J].

Shen, Jia ;

Poole, Joseph C. ;

Topel, Matthew L. ;

Bidulescu, Aurelian ;

Morris, Alanna A. ;

Patel, Riyaz S. ;

Binongo, Jose G. ;

Dunbar, Sandra B. ;

Phillips, Lawrence ;

Vaccarino, Viola ;

Gibbons, Gary H. ;

Quyyumi, Arshed A. .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2015, 100 (11) :4231-4239

[47] Subclinical Cardiac Dysfunction and Brain Health in Midlife: CARDIA (Coronary Artery Risk Development in Young Adults) Brain Magnetic Resonance Imaging Substudy [J].

Cermakova, Pavla ;

Muller, Majon ;

Armstrong, Anderson C. ;

Religa, Dorota ;

Bryan, R. Nick ;

Lima, Joao A. C. ;

Launer, Lenore J. .

JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2017, 6 (12)

[48] Association Between Metabolic Syndrome and Atopic Dermatitis in Korean Adults [J].

Lee, Ji Hyun ;

Jung, Han Mi ;

Do Han, Kyung ;

Lee, Seung-Hwan ;

Lee, Jun Young ;

Park, Yong Gyu ;

Park, Young Min .

ACTA DERMATO-VENEREOLOGICA, 2017, 97 (01) :77-80

[49] The association between noodle consumption and metabolic syndrome in Korean adults [J].

Jeon, Da Eun ;

Kim, Youngyo .

ASIA PACIFIC JOURNAL OF CLINICAL NUTRITION, 2025, 34 (02) :193-201

[50] Association between Thigh Muscle Development and the Metabolic Syndrome in Adults [J].

Londono, Francisco J. ;

Calderon, Juan C. ;

Gallo, Jaime .

ANNALS OF NUTRITION AND METABOLISM, 2012, 61 (01) :41-46

← 1 2 3 4 5 →