The Association of Metabolic Syndrome with Executive Dysfunction Independent of Subclinical Ischemic Brain Lesions in Japanese Adults

被引：34

作者：

Bokura, Hirokazu ^{[1
]}

Nagai, Atsushi ^{[2
]}

Oguro, Hiroaki ^{[1
]}

Kobayashi, Shotai ^{[3
]}

Yamaguchi, Shuhei ^{[1
]}

机构：

[1] Shimane Univ, Fac Med, Dept Neurol, Izumo, Shimane 6938501, Japan

[2] Shimane Univ, Fac Med, Dept Lab Med, Izumo, Shimane 6938501, Japan

[3] Shimane Univ Hosp, Izumo, Shimane, Japan

来源：

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS | 2010年 / 30卷 / 06期

关键词：

Metabolic syndrome; Cognitive impairment; Executive function; Brain lesions; Glucose metabolism; FRONTAL ASSESSMENT BATTERY; WHITE-MATTER CHANGES; MIDDLE-AGED MEN; ALZHEIMERS-DISEASE; COGNITIVE IMPAIRMENT; INSULIN-RESISTANCE; VASCULAR DEMENTIA; RISK-FACTORS; DIABETES-MELLITUS; BLOOD-PRESSURE;

D O I：

10.1159/000322057

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Background/Aims: The aim of this study is to examine whether metabolic syndrome is directly associated with cognitive impairment independent of subclinical ischemic brain lesions. Methods: We examined 1,543 neurologically normal subjects (44-86 years of age). Metabolic syndrome, brain MRI, and cognitive functions including general cognition and executive function were assessed. Results: After adjusting for silent brain lesions and demographic risk factors, metabolic syndrome was an independent risk factor for impairment of executive function (OR = 1.41, 95% CI = 1.17-1.25 for Kohs' Test; OR = 2.25, 95% CI = 1.64-3.07 for Frontal Assessment Battery). Among the components of metabolic syndrome, elevated fasting glucose was the only independent risk factor for impairment of executive function. Conclusion: Metabolic syndrome is associated with impairment of executive function independent of silent brain lesions in the Japanese population. Copyright (C) 2011 S. Karger AG, Basel

引用

页码：479 / 485

页数：7

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