Clinical Presentation and Pathophysiology of Gastroparesis

被引：40
作者：
Nguyen, Linda Anh [1 ]
Snape, William J., Jr. [2 ]
机构：
[1] Stanford Univ, Dept Med, Div Gastroenterol, Palo Alto, CA 94305 USA
[2] Calif Pacific Med Ctr, Dept Med, Div Gastroenterol, San Francisco, CA 94115 USA
来源：
GASTROENTEROLOGY CLINICS OF NORTH AMERICA | 2015年 / 44卷 / 01期
关键词：
Gastroparesis; Pathophysiology; 0; Gastric motor function; Gastric emptying; Visceral hypersensitivity; Gastric accommodation; GASTRIC SENSORIMOTOR FUNCTION; IRRITABLE-BOWEL-SYNDROME; FUNCTIONAL DYSPEPSIA; BOTULINUM-TOXIN; DIABETIC GASTROPARESIS; SYMPTOM SEVERITY; VISCERAL HYPERSENSITIVITY; CONTROLLED-TRIAL; DISTENSION; MOTILITY;
D O I：
10.1016/j.gtc.2014.11.003
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Gastroparesis is a heterogeneous disorder defined by delay in gastric emptying. Symptoms of gastroparesis are nonspecific, including nausea, vomiting, early satiety, bloating, and/or abdominal pain. Normal gastric motor function and sensory function depend on a complex coordination between the enteric and central nervous system. This article discusses the pathophysiology of delayed gastric emptying and the symptoms of gastroparesis, including antropyloroduodenal dysmotility, impaired gastric accommodation, visceral hypersensitivity, and autonomic dysfunction. The underlying pathophysiology of gastroparesis is complex and multifactorial.The article discusses how a combination of these factors leads to symptoms of gastroparesis.
引用
收藏
页码：21 / +
页数：12
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