Mitochondrial antigens as targets of cellular and humoral auto-immunity in primary biliary cirrhosis

被引：20
作者：
Ichiki, Y
Selmi, C
Shimoda, S
Ishibashi, H
Gordon, SC
Gershwin, ME
机构：
[1] Univ Calif Davis, Sch Med, Div Rheumatol Allergy & Clin Immunol, Davis, CA 95616 USA
[2] Kyushu Univ, Grad Sch Med Sci, Higashi Ku, Fukuoka 8128582, Japan
[3] Nagasaki Med Ctr, Clin Res Ctr, Nagasaki 8568562, Japan
[4] William Beaumont Hosp, Div Gastroenterol Hepatol, Royal Oak, MI 48072 USA
来源：
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY | 2005年 / 28卷 / 02期
关键词：
auto-immunity; auto-antibody; auto-epitope; primary biliary cirrhosis; 2-oxo-acid dehydrogenase complex; pyruvate dehydrogenase complex;
D O I：
10.1385/CRIAI:28:2:083
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
Several factors point toward an auto-immune pathogenesis for primary biliary cirrhosis (PBC), mostly based on the presence of serum auto-antibodies to mitochondrial antigens (AMAs) and autoreactive T cells (both helper and cytotoxic). Interestingly, epitopes recognized by AMA and T-cell clones are located within overlapping areas of the antigens. Moreover, a role for an imbalance in cytokine pattern and for natural-killer lymphocytes has also been proposed. Despite several experimental reports, no clear evidence is available regarding the interaction of these factors leading to bile duct destruction. This article reviews the current reports regarding the auto-immune reaction against mitochondrial auto-antigens in PBC.
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收藏
页码：83 / 91
页数：9
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