Multi-organ Metastasis of Fibrolamellar Hepatocellular Carcinoma in a Malayan Gharial (Tomistoma schlegelii)

被引:1
|
作者
Ahmad, A. A. [1 ]
Dorrestein, G. M. [2 ]
Oh, S. J. W. Y. [1 ]
Hsu, C. D. [1 ]
机构
[1] Wildlife Reserve Singapore, Dept Vet Serv, Singapore, Singapore
[2] Zoo Veldhoven, Pathol Lab NOIVBD, Wintelresedijk 51, Veldhoven, Netherlands
关键词
fibrolamellar hepatocellular carcinoma; Malayan gharial; metastasis; Tomistoma schlegelii; SQUAMOUS-CELL CARCINOMA; FIBROSARCOMA; SURVIVAL; TUMOR;
D O I
10.1016/j.jcpa.2017.06.007
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
A 38-year-old Malayan gharial (Tomistoma schlegelii) with a 2-week history of anorexia was found dead and presented for post-mortem examination. Numerous white firm nodules of various sizes were found on the surface of the liver, both left and right kidneys, the spleen and the serosa of the intestinal tract. All masses had similar microscopical appearance and were diagnosed as metastasizing fibrolamellar hepatocellular carcinoma. Immunohistochemically, the tumour cells did not react with antibodies specific for pan-cytokeratin, vimentin or HepPar-1. The anti-HepPar-1 and anti-pan-cytokeratin antibodies also did not react with normal hepatocytes or exocrine pancreatic cells. This is the first description of fibrolamellar hepatocellular carcinoma with metastases in a crocodilian. (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码:80 / 84
页数:5
相关论文
共 50 条
  • [31] Multi-organ early tumor dissemination after high urgency re-transplantation for hepatocellular carcinoma in cirrhosis:: Role of massive intraoperative transfusion?
    Sotiropoulos, Georgios C.
    Beckebaum, Susanne
    Molmenti, Ernesto P.
    Klein, Christian G.
    Cicinnati, Vito R.
    Broelsch, Christoph E.
    Malago, Massimo
    DIGESTIVE DISEASES AND SCIENCES, 2008, 53 (04) : 1156 - 1157
  • [32] Multi-organ Early Tumor Dissemination After High Urgency Re-transplantation for Hepatocellular Carcinoma in Cirrhosis: Role of Massive Intraoperative Transfusion?
    Georgios C. Sotiropoulos
    Susanne Beckebaum
    Ernesto P. Molmenti
    Christian G. Klein
    Vito R. Cicinnati
    Christoph E. Broelsch
    Massimo Malagó
    Digestive Diseases and Sciences, 2008, 53 : 1156 - 1157
  • [33] Site-Specific Metastasis and Survival in Papillary Thyroid Cancer: The Importance of Brain and Multi-Organ Disease
    Toraih, Eman A.
    Hussein, Mohammad H.
    Zerfaoui, Mourad
    Attia, Abdallah S.
    Marzouk Ellythy, Assem
    Mostafa, Arwa
    Ruiz, Emmanuelle M. L.
    Shama, Mohamed Ahmed
    Russell, Jonathon O.
    Randolph, Gregory W.
    Kandil, Emad
    CANCERS, 2021, 13 (07)
  • [34] Local recurrence and multi-organ metastasis of primary retroperitoneal leiomyosarcoma in unusual locations after surgical resection
    Lal, Hira
    Neyaz, Zafar
    Kapoor, Vinay Kumar
    Pottakkat, Biju
    Gupta, Pallav
    JOURNAL OF RADIOLOGY CASE REPORTS, 2011, 5 (06): : 1 - 8
  • [35] Soluble Vegfr3 gene therapy suppresses multi-organ metastasis in a mouse mammary cancer model
    Shibata, Masa-Aki
    Shibata, Eiko
    Tanaka, Yoshihisa
    Shiraoka, Chinatsu
    Kondo, Yoichi
    CANCER SCIENCE, 2020, 111 (08) : 2837 - 2849
  • [36] Pulmonary Lymphangitic Carcinomatosis: An Atypical Presentation Leading to Discovery of Multi-Organ Metastasis With Unknown Occult Primary Malignancy
    Al-Bayati, Mustafa
    Al-Jobory, Ola
    Abu-hassan, Falah
    Mohammed, Basheer U.
    Yaqoob, Sinan
    Bazzaz, Omar
    CUREUS JOURNAL OF MEDICAL SCIENCE, 2022, 14 (08)
  • [37] Long survival in a pancreatic carcinoma patient with multi-organ toxicities after sintilimab treatment: A case report
    Ni, Chen-Xu
    Zhao, Yu
    Qian, Hong
    Fu, Hui
    Yan, Yu-Ying
    Qiu, Yu-Shuang
    Zhou, Can-Can
    Huang, Fang
    Shen, Fu-Ming
    Li, Dong-Jie
    Xu, Qing
    FRONTIERS IN PHARMACOLOGY, 2023, 14
  • [38] ASPH-notch Axis guided Exosomal delivery of Prometastatic Secretome renders breast Cancer multi-organ metastasis
    Lin, Qiushi
    Chen, Xuesong
    Meng, Fanzheng
    Ogawa, Kosuke
    Li, Min
    Song, Ruipeng
    Zhang, Shugeng
    Zhang, Ziran
    Kong, Xianglu
    Xu, Qinggang
    He, Fuliang
    Bai, Xuewei
    Sun, Bei
    Hung, Mien-Chie
    Liu, Lianxin
    Wands, Jack
    Dong, Xiaoqun
    MOLECULAR CANCER, 2019, 18 (01)
  • [39] Next generation sequencing reveals the phylogenetic relationship of multi-organ metastatic colon cancer and molecular determinants of metastasis.
    Hu, Dandan
    Chen, Gong
    Zhang, Yaojun
    Chen, Minshan
    JOURNAL OF CLINICAL ONCOLOGY, 2020, 38 (15)
  • [40] Role of kruppel-like factor 8 for therapeutic drug-resistant multi-organ metastasis of breast cancer
    Hao, Jie
    Lu, Heng
    Mukherjee, Debarati
    Yu, Lin
    Zhao, Jihe
    AMERICAN JOURNAL OF CANCER RESEARCH, 2021, 11 (05): : 2188 - 2201