Multi-organ Metastasis of Fibrolamellar Hepatocellular Carcinoma in a Malayan Gharial (Tomistoma schlegelii)

被引：1
|
作者：
Ahmad, A. A. [1 ]
Dorrestein, G. M. [2 ]
Oh, S. J. W. Y. [1 ]
Hsu, C. D. [1 ]
机构：
[1] Wildlife Reserve Singapore, Dept Vet Serv, Singapore, Singapore
[2] Zoo Veldhoven, Pathol Lab NOIVBD, Wintelresedijk 51, Veldhoven, Netherlands
来源：
JOURNAL OF COMPARATIVE PATHOLOGY | 2017年 / 157卷 / 2-3期
关键词：
fibrolamellar hepatocellular carcinoma; Malayan gharial; metastasis; Tomistoma schlegelii; SQUAMOUS-CELL CARCINOMA; FIBROSARCOMA; SURVIVAL; TUMOR;
D O I：
10.1016/j.jcpa.2017.06.007
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
A 38-year-old Malayan gharial (Tomistoma schlegelii) with a 2-week history of anorexia was found dead and presented for post-mortem examination. Numerous white firm nodules of various sizes were found on the surface of the liver, both left and right kidneys, the spleen and the serosa of the intestinal tract. All masses had similar microscopical appearance and were diagnosed as metastasizing fibrolamellar hepatocellular carcinoma. Immunohistochemically, the tumour cells did not react with antibodies specific for pan-cytokeratin, vimentin or HepPar-1. The anti-HepPar-1 and anti-pan-cytokeratin antibodies also did not react with normal hepatocytes or exocrine pancreatic cells. This is the first description of fibrolamellar hepatocellular carcinoma with metastases in a crocodilian. (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码：80 / 84
页数：5
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