The Development of SPE Procedures and an UHPLC Method for the Simultaneous Determination of Ten Drugs in Water Samples

被引:47
作者
Baranowska, Irena [1 ]
Kowalski, Bartosz [1 ]
机构
[1] Silesian Tech Univ, Fac Chem, Dept Analyt & Gen Chem, PL-44100 Gliwice, Poland
关键词
Pharmaceuticals; Water samples; Ultra HPLC; SPE columns; TANDEM MASS-SPECTROMETRY; SOLID-PHASE EXTRACTION; PRESSURE LIQUID-CHROMATOGRAPHY; TRACE-LEVEL DETERMINATION; SEWAGE-TREATMENT PLANT; WASTE-WATER; SURFACE-WATER; GAS-CHROMATOGRAPHY; PHARMACEUTICAL COMPOUNDS; THERAPEUTIC CLASSES;
D O I
10.1007/s11270-009-0310-7
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Analytical procedures for the determination of pharmaceuticals from different therapeutic groups were proposed. These groups included the corticosteroids prednisolone and dexamethasone; the beta-blockers sotalol, metoprolol, propranolol, and carvedilol; and the analgesic nonsteroidal anti-inflammatory drugs paracetamol, aspirin, metamizole, and ketoprofen. Reversed-phase ultrahigh performance liquid chromatography with an ultraviolet detector, different columns, different mobile phases, and gradient elution programmes were used to obtain the best separations within the shortest possible time. Solid-phase extraction was examined as a preconcentration step. The Oasis HLB column, with the highest recoveries (over 90% for most of the drugs), was chosen for the analysis of surface waters. Limits of detection ranged from 0.06 to 0.39 mu g L(-1) for all drugs after optimisation of all analytical steps.
引用
收藏
页码:417 / 425
页数:9
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