Role of Transient Receptor Potential Channels in Intestinal Inflammation and Visceral Pain: Novel Targets in Inflammatory Bowel Diseases

被引:43
作者
Zielinska, Marta [1 ]
Jarmuz, Agata [1 ]
Wasilewski, Andrzej [1 ]
Salaga, Maciej [1 ]
Fichna, Jakub [1 ]
机构
[1] Med Univ Lodz, Dept Biochem, Fac Med, PL-92215 Lodz, Poland
关键词
capsaicin receptor; Crohn's disease; experimental colitis; TRP channels; ulcerative colitis; visceral hypersensitivity; SODIUM-INDUCED COLITIS; ROOT GANGLION NEURONS; TRPM2; ION-CHANNEL; SENSORY NEURONS; VANILLOID RECEPTOR-1; CAPSAICIN RECEPTOR; NEUROGENIC INFLAMMATION; OXIDATIVE STRESS; AFFERENT NEURONS; MOUSE INTESTINE;
D O I
10.1097/MIB.0000000000000234
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Transient receptor potential (TRP) channels are a large group of ion channels that are prevalent in mammalian tissues. They are widely distributed in the central and peripheral nervous systems, and in nonneuronal cells, where they are implicated in sensing temperature, noxious substances, and pain. TRPs play an important role in immune response and nociception and, therefore, may be involved in the pathogenesis of inflammatory bowel diseases, whose major symptoms include chronic inflammatory state and abdominal pain. In this review, we summarize what is known on TRP channels in inflammatory bowel disease and visceral pain; we focus in particular on TRPV1, TRPV4, TRPA1, and TRPM. We also analyze scientific reports that evidence potential use of TRP regulators in future inflammatory bowel disease treatment.
引用
收藏
页码:419 / 427
页数:9
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