Glioblastoma multiforme is a high grade malignant brain tumour with a poor prognosis. Here we report the case of a woman with glioblastoma who lived for over four years from diagnosis (median survival 12 months and 2% survival for three years), experiencing good quality of life for most of that time. She underwent initial debulking craniotomy, radiotherapy and chemotherapy, as well as having intravenous vitamin C infusions 2-3 times weekly over the four years from diagnosis. Her progress was monitored by blood tests, regular computerised tomography (CT) and magnetic resonance imaging (MRI) scans, clinical reviews and European Organization for the Research and Treatment of Cancer quality of life questionnaires (EORTC QLQ C30). Our case report highlights the benefits of intravenous vitamin C as a supportive therapy for patients with glioblastoma.
机构:
Univ Otago, Ctr Free Rad Res, Dept Pathol, POB 4345, Christchurch 8140, New ZealandUniv Otago, Ctr Free Rad Res, Dept Pathol, POB 4345, Christchurch 8140, New Zealand
Carr, Anitra C.
;
Vissers, Margreet C. M.
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Univ Otago, Ctr Free Rad Res, Dept Pathol, POB 4345, Christchurch 8140, New ZealandUniv Otago, Ctr Free Rad Res, Dept Pathol, POB 4345, Christchurch 8140, New Zealand
Vissers, Margreet C. M.
;
Cook, John S.
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h-index: 0
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New Brighton Hlth Care, Christchurch, New ZealandUniv Otago, Ctr Free Rad Res, Dept Pathol, POB 4345, Christchurch 8140, New Zealand
机构:
Univ Iowa, Coll Med, Dept Radiat Oncol, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Iowa City, IA 52242 USA
Du, Juan
;
Martin, Sean M.
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Univ Iowa, Coll Med, Dept Pathol, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Iowa City, IA 52242 USA
Martin, Sean M.
;
Levine, Mark
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h-index: 0
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NIDDKD, Mol & Clin Nutr Sect, Digest Dis Branch, NIH, Bethesda, MD 20892 USAUniv Iowa, Coll Med, Dept Surg, Iowa City, IA 52242 USA
Levine, Mark
;
Wagner, Brett A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Coll Med, Dept Radiat Oncol, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Iowa City, IA 52242 USA
Wagner, Brett A.
;
Buettner, Garry R.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Coll Med, Dept Radiat Oncol, Iowa City, IA 52242 USA
Holden Comprehens Canc Ctr, Iowa City, IA USAUniv Iowa, Coll Med, Dept Surg, Iowa City, IA 52242 USA
Buettner, Garry R.
;
Wang, Sih-han
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Coll Med, Dept Pathol, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Iowa City, IA 52242 USA
Wang, Sih-han
;
Taghiyev, Agshin F.
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h-index: 0
机构:
Univ Iowa, Coll Med, Dept Pathol, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Iowa City, IA 52242 USA
Taghiyev, Agshin F.
;
Du, Changbin
论文数: 0引用数: 0
h-index: 0
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Univ Iowa, Coll Med, Dept Radiat Oncol, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Iowa City, IA 52242 USA
Du, Changbin
;
Knudson, Charles M.
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h-index: 0
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Univ Iowa, Coll Med, Dept Pathol, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Iowa City, IA 52242 USA
Knudson, Charles M.
;
Cullen, Joseph J.
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机构:
Univ Iowa, Coll Med, Dept Surg, Iowa City, IA 52242 USA
Univ Iowa, Coll Med, Dept Radiat Oncol, Iowa City, IA 52242 USA
Holden Comprehens Canc Ctr, Iowa City, IA USA
Vet Affairs Med Ctr, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Iowa City, IA 52242 USA
机构:
Marshall Univ, Joan C Edwards Sch Med, Dept Biomed Sci, One John Marshall Dr, Huntington, WV 25755 USAMarshall Univ, Joan C Edwards Sch Med, Dept Biomed Sci, One John Marshall Dr, Huntington, WV 25755 USA
Fischer, Adam P.
;
Miles, Sarah L.
论文数: 0引用数: 0
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Marshall Univ, Joan C Edwards Sch Med, Dept Biomed Sci, One John Marshall Dr, Huntington, WV 25755 USAMarshall Univ, Joan C Edwards Sch Med, Dept Biomed Sci, One John Marshall Dr, Huntington, WV 25755 USA
机构:
Virginia Commonwealth Univ, Dept Internal Med, Sch Med, Div Pulm Dis & Crit Care Med, Richmond, VA 23298 USAVirginia Commonwealth Univ, Dept Internal Med, Sch Med, Div Pulm Dis & Crit Care Med, Richmond, VA 23298 USA
Fowler, Alpha A., III
;
Syed, Aamer A.
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Virginia Commonwealth Univ, Dept Internal Med, Sch Med, Div Pulm Dis & Crit Care Med, Richmond, VA 23298 USAVirginia Commonwealth Univ, Dept Internal Med, Sch Med, Div Pulm Dis & Crit Care Med, Richmond, VA 23298 USA
Syed, Aamer A.
;
Knowlson, Shelley
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Virginia Commonwealth Univ Hlth Syst, Dept Crit Care Nursing, Richmond, VA USAVirginia Commonwealth Univ, Dept Internal Med, Sch Med, Div Pulm Dis & Crit Care Med, Richmond, VA 23298 USA
Knowlson, Shelley
;
Sculthorpe, Robin
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Virginia Commonwealth Univ, Sch Pharm, Dept Pharm Serv, Invest Drug Serv, Richmond, VA 23298 USAVirginia Commonwealth Univ, Dept Internal Med, Sch Med, Div Pulm Dis & Crit Care Med, Richmond, VA 23298 USA
Sculthorpe, Robin
;
Farthing, Don
论文数: 0引用数: 0
h-index: 0
机构:
Virginia Commonwealth Univ, Sch Med, Dept Internal Med, Div Nephrol, Richmond, VA 23298 USAVirginia Commonwealth Univ, Dept Internal Med, Sch Med, Div Pulm Dis & Crit Care Med, Richmond, VA 23298 USA
Farthing, Don
;
DeWilde, Christine
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机构:
Virginia Commonwealth Univ, Dept Internal Med, Sch Med, Div Pulm Dis & Crit Care Med, Richmond, VA 23298 USAVirginia Commonwealth Univ, Dept Internal Med, Sch Med, Div Pulm Dis & Crit Care Med, Richmond, VA 23298 USA
DeWilde, Christine
;
Farthing, Christine A.
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机构:
Virginia Commonwealth Univ, Sch Med, Dept Internal Med, Div Nephrol, Richmond, VA 23298 USAVirginia Commonwealth Univ, Dept Internal Med, Sch Med, Div Pulm Dis & Crit Care Med, Richmond, VA 23298 USA
Farthing, Christine A.
;
Larus, Terri L.
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Virginia Commonwealth Univ, Sch Med, Dept Internal Med, Div Nephrol, Richmond, VA 23298 USAVirginia Commonwealth Univ, Dept Internal Med, Sch Med, Div Pulm Dis & Crit Care Med, Richmond, VA 23298 USA
Larus, Terri L.
;
Martin, Erika
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Virginia Commonwealth Univ, Sch Pharm, Dept Pharmacotherapy & Outcomes Sci, Richmond, VA 23298 USAVirginia Commonwealth Univ, Dept Internal Med, Sch Med, Div Pulm Dis & Crit Care Med, Richmond, VA 23298 USA
Martin, Erika
;
Brophy, Donald F.
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Virginia Commonwealth Univ, Sch Pharm, Dept Pharmacotherapy & Outcomes Sci, Richmond, VA 23298 USAVirginia Commonwealth Univ, Dept Internal Med, Sch Med, Div Pulm Dis & Crit Care Med, Richmond, VA 23298 USA
Brophy, Donald F.
;
Gupta, Seema
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机构:
Hlth Diagnost Lab, Richmond, VA USAVirginia Commonwealth Univ, Dept Internal Med, Sch Med, Div Pulm Dis & Crit Care Med, Richmond, VA 23298 USA
Gupta, Seema
;
Fisher, Bernard J.
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机构:
Virginia Commonwealth Univ, Dept Internal Med, Sch Med, Div Pulm Dis & Crit Care Med, Richmond, VA 23298 USAVirginia Commonwealth Univ, Dept Internal Med, Sch Med, Div Pulm Dis & Crit Care Med, Richmond, VA 23298 USA
Fisher, Bernard J.
;
Natarajan, Ramesh
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Virginia Commonwealth Univ, Dept Internal Med, Sch Med, Div Pulm Dis & Crit Care Med, Richmond, VA 23298 USAVirginia Commonwealth Univ, Dept Internal Med, Sch Med, Div Pulm Dis & Crit Care Med, Richmond, VA 23298 USA
机构:
Univ Otago, Ctr Free Rad Res, Dept Pathol, POB 4345, Christchurch 8140, New ZealandUniv Otago, Ctr Free Rad Res, Dept Pathol, POB 4345, Christchurch 8140, New Zealand
Carr, Anitra C.
;
Vissers, Margreet C. M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Otago, Ctr Free Rad Res, Dept Pathol, POB 4345, Christchurch 8140, New ZealandUniv Otago, Ctr Free Rad Res, Dept Pathol, POB 4345, Christchurch 8140, New Zealand
Vissers, Margreet C. M.
;
Cook, John S.
论文数: 0引用数: 0
h-index: 0
机构:
New Brighton Hlth Care, Christchurch, New ZealandUniv Otago, Ctr Free Rad Res, Dept Pathol, POB 4345, Christchurch 8140, New Zealand
机构:
Univ Iowa, Coll Med, Dept Radiat Oncol, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Iowa City, IA 52242 USA
Du, Juan
;
Martin, Sean M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Coll Med, Dept Pathol, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Iowa City, IA 52242 USA
Martin, Sean M.
;
Levine, Mark
论文数: 0引用数: 0
h-index: 0
机构:
NIDDKD, Mol & Clin Nutr Sect, Digest Dis Branch, NIH, Bethesda, MD 20892 USAUniv Iowa, Coll Med, Dept Surg, Iowa City, IA 52242 USA
Levine, Mark
;
Wagner, Brett A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Coll Med, Dept Radiat Oncol, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Iowa City, IA 52242 USA
Wagner, Brett A.
;
Buettner, Garry R.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Coll Med, Dept Radiat Oncol, Iowa City, IA 52242 USA
Holden Comprehens Canc Ctr, Iowa City, IA USAUniv Iowa, Coll Med, Dept Surg, Iowa City, IA 52242 USA
Buettner, Garry R.
;
Wang, Sih-han
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Coll Med, Dept Pathol, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Iowa City, IA 52242 USA
Wang, Sih-han
;
Taghiyev, Agshin F.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Coll Med, Dept Pathol, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Iowa City, IA 52242 USA
Taghiyev, Agshin F.
;
Du, Changbin
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Coll Med, Dept Radiat Oncol, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Iowa City, IA 52242 USA
Du, Changbin
;
Knudson, Charles M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Coll Med, Dept Pathol, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Iowa City, IA 52242 USA
Knudson, Charles M.
;
Cullen, Joseph J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Coll Med, Dept Surg, Iowa City, IA 52242 USA
Univ Iowa, Coll Med, Dept Radiat Oncol, Iowa City, IA 52242 USA
Holden Comprehens Canc Ctr, Iowa City, IA USA
Vet Affairs Med Ctr, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Iowa City, IA 52242 USA
机构:
Marshall Univ, Joan C Edwards Sch Med, Dept Biomed Sci, One John Marshall Dr, Huntington, WV 25755 USAMarshall Univ, Joan C Edwards Sch Med, Dept Biomed Sci, One John Marshall Dr, Huntington, WV 25755 USA
Fischer, Adam P.
;
Miles, Sarah L.
论文数: 0引用数: 0
h-index: 0
机构:
Marshall Univ, Joan C Edwards Sch Med, Dept Biomed Sci, One John Marshall Dr, Huntington, WV 25755 USAMarshall Univ, Joan C Edwards Sch Med, Dept Biomed Sci, One John Marshall Dr, Huntington, WV 25755 USA
机构:
Virginia Commonwealth Univ, Dept Internal Med, Sch Med, Div Pulm Dis & Crit Care Med, Richmond, VA 23298 USAVirginia Commonwealth Univ, Dept Internal Med, Sch Med, Div Pulm Dis & Crit Care Med, Richmond, VA 23298 USA
Fowler, Alpha A., III
;
Syed, Aamer A.
论文数: 0引用数: 0
h-index: 0
机构:
Virginia Commonwealth Univ, Dept Internal Med, Sch Med, Div Pulm Dis & Crit Care Med, Richmond, VA 23298 USAVirginia Commonwealth Univ, Dept Internal Med, Sch Med, Div Pulm Dis & Crit Care Med, Richmond, VA 23298 USA
Syed, Aamer A.
;
Knowlson, Shelley
论文数: 0引用数: 0
h-index: 0
机构:
Virginia Commonwealth Univ Hlth Syst, Dept Crit Care Nursing, Richmond, VA USAVirginia Commonwealth Univ, Dept Internal Med, Sch Med, Div Pulm Dis & Crit Care Med, Richmond, VA 23298 USA
Knowlson, Shelley
;
Sculthorpe, Robin
论文数: 0引用数: 0
h-index: 0
机构:
Virginia Commonwealth Univ, Sch Pharm, Dept Pharm Serv, Invest Drug Serv, Richmond, VA 23298 USAVirginia Commonwealth Univ, Dept Internal Med, Sch Med, Div Pulm Dis & Crit Care Med, Richmond, VA 23298 USA
Sculthorpe, Robin
;
Farthing, Don
论文数: 0引用数: 0
h-index: 0
机构:
Virginia Commonwealth Univ, Sch Med, Dept Internal Med, Div Nephrol, Richmond, VA 23298 USAVirginia Commonwealth Univ, Dept Internal Med, Sch Med, Div Pulm Dis & Crit Care Med, Richmond, VA 23298 USA
Farthing, Don
;
DeWilde, Christine
论文数: 0引用数: 0
h-index: 0
机构:
Virginia Commonwealth Univ, Dept Internal Med, Sch Med, Div Pulm Dis & Crit Care Med, Richmond, VA 23298 USAVirginia Commonwealth Univ, Dept Internal Med, Sch Med, Div Pulm Dis & Crit Care Med, Richmond, VA 23298 USA
DeWilde, Christine
;
Farthing, Christine A.
论文数: 0引用数: 0
h-index: 0
机构:
Virginia Commonwealth Univ, Sch Med, Dept Internal Med, Div Nephrol, Richmond, VA 23298 USAVirginia Commonwealth Univ, Dept Internal Med, Sch Med, Div Pulm Dis & Crit Care Med, Richmond, VA 23298 USA
Farthing, Christine A.
;
Larus, Terri L.
论文数: 0引用数: 0
h-index: 0
机构:
Virginia Commonwealth Univ, Sch Med, Dept Internal Med, Div Nephrol, Richmond, VA 23298 USAVirginia Commonwealth Univ, Dept Internal Med, Sch Med, Div Pulm Dis & Crit Care Med, Richmond, VA 23298 USA
Larus, Terri L.
;
Martin, Erika
论文数: 0引用数: 0
h-index: 0
机构:
Virginia Commonwealth Univ, Sch Pharm, Dept Pharmacotherapy & Outcomes Sci, Richmond, VA 23298 USAVirginia Commonwealth Univ, Dept Internal Med, Sch Med, Div Pulm Dis & Crit Care Med, Richmond, VA 23298 USA
Martin, Erika
;
Brophy, Donald F.
论文数: 0引用数: 0
h-index: 0
机构:
Virginia Commonwealth Univ, Sch Pharm, Dept Pharmacotherapy & Outcomes Sci, Richmond, VA 23298 USAVirginia Commonwealth Univ, Dept Internal Med, Sch Med, Div Pulm Dis & Crit Care Med, Richmond, VA 23298 USA
Brophy, Donald F.
;
Gupta, Seema
论文数: 0引用数: 0
h-index: 0
机构:
Hlth Diagnost Lab, Richmond, VA USAVirginia Commonwealth Univ, Dept Internal Med, Sch Med, Div Pulm Dis & Crit Care Med, Richmond, VA 23298 USA
Gupta, Seema
;
Fisher, Bernard J.
论文数: 0引用数: 0
h-index: 0
机构:
Virginia Commonwealth Univ, Dept Internal Med, Sch Med, Div Pulm Dis & Crit Care Med, Richmond, VA 23298 USAVirginia Commonwealth Univ, Dept Internal Med, Sch Med, Div Pulm Dis & Crit Care Med, Richmond, VA 23298 USA
Fisher, Bernard J.
;
Natarajan, Ramesh
论文数: 0引用数: 0
h-index: 0
机构:
Virginia Commonwealth Univ, Dept Internal Med, Sch Med, Div Pulm Dis & Crit Care Med, Richmond, VA 23298 USAVirginia Commonwealth Univ, Dept Internal Med, Sch Med, Div Pulm Dis & Crit Care Med, Richmond, VA 23298 USA