The Use of Intravenous Vitamin C as a Supportive Therapy for a Patient with Glioblastoma Multiforme

被引:17
作者
Baillie, Nicola [1 ]
Carr, Anitra C. [2 ]
Peng, Selene [3 ]
机构
[1] Integrated Hlth Opt Ltd, Auckland 1050, New Zealand
[2] Univ Otago, Dept Pathol & Biomed Sci, Christchurch 8140, New Zealand
[3] Feedback Res Ltd, Auckland 1050, New Zealand
关键词
vitamin C; intravenous vitamin C; ascorbic acid; glioblastoma; neoplasms; quality of life; ASCORBATE-INDUCED CYTOTOXICITY; I CLINICAL-TRIAL; CANCER-CELLS; PHARMACOLOGICAL ASCORBATE; HYDROGEN-PEROXIDE; PANCREATIC-CANCER; ACID;
D O I
10.3390/antiox7090115
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Glioblastoma multiforme is a high grade malignant brain tumour with a poor prognosis. Here we report the case of a woman with glioblastoma who lived for over four years from diagnosis (median survival 12 months and 2% survival for three years), experiencing good quality of life for most of that time. She underwent initial debulking craniotomy, radiotherapy and chemotherapy, as well as having intravenous vitamin C infusions 2-3 times weekly over the four years from diagnosis. Her progress was monitored by blood tests, regular computerised tomography (CT) and magnetic resonance imaging (MRI) scans, clinical reviews and European Organization for the Research and Treatment of Cancer quality of life questionnaires (EORTC QLQ C30). Our case report highlights the benefits of intravenous vitamin C as a supportive therapy for patients with glioblastoma.
引用
收藏
页数:6
相关论文
共 25 条
[1]   A comparison of long-term survivors and short-term survivors with glioblastoma, subventricular zone involvement: a predictive factor for survival? [J].
Adeberg, Sebastian ;
Bostel, Tilman ;
Koenig, Laila ;
Welzel, Thomas ;
Debus, Juergen ;
Combs, Stephanie E. .
RADIATION ONCOLOGY, 2014, 9
[2]   SUPPLEMENTAL ASCORBATE IN SUPPORTIVE TREATMENT OF CANCER - PROLONGATION OF SURVIVAL TIMES IN TERMINAL HUMAN CANCER .1. [J].
CAMERON, E ;
PAULING, L .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1976, 73 (10) :3685-3689
[3]   Pharmacokinetic and anti-cancer properties of high dose ascorbate in solid tumours of ascorbate-dependent mice [J].
Campbell, Elizabeth J. ;
Vissers, Margreet C. M. ;
Wohlrab, Christina ;
Hicks, Kevin O. ;
Strother, R. Matthew ;
Bozonet, Stephanie M. ;
Robinson, Bridget A. ;
Dachs, Gabi U. .
FREE RADICAL BIOLOGY AND MEDICINE, 2016, 99 :451-462
[4]   The effect of intravenous vitamin C on cancer- and chemotherapy-related fatigue and quality of life [J].
Carr, Anitra C. ;
Vissers, Margreet C. M. ;
Cook, John S. .
FRONTIERS IN ONCOLOGY, 2014, 4
[5]   Pharmacologic ascorbic acid concentrations selectively kill cancer cells: Action as a pro-drug to deliver hydrogen peroxide to tissues [J].
Chen, Q ;
Espey, MG ;
Krishna, MC ;
Mitchell, JB ;
Corpe, CP ;
Buettner, GR ;
Shacter, E ;
Levine, M .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (38) :13604-13609
[6]   Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo [J].
Chen, Qi ;
Espey, Michael Graham ;
Sun, Andrew Y. ;
Lee, Je-Hyuk ;
Krishna, Murali C. ;
Shacter, Emily ;
Choyke, Peter L. ;
Pooput, Chaya ;
Kirk, Kenneth L. ;
Buettner, Garry R. ;
Levine, Mark .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (21) :8749-8754
[7]   Mechanisms of Ascorbate-Induced Cytotoxicity in Pancreatic Cancer [J].
Du, Juan ;
Martin, Sean M. ;
Levine, Mark ;
Wagner, Brett A. ;
Buettner, Garry R. ;
Wang, Sih-han ;
Taghiyev, Agshin F. ;
Du, Changbin ;
Knudson, Charles M. ;
Cullen, Joseph J. .
CLINICAL CANCER RESEARCH, 2010, 16 (02) :509-520
[8]   Ascorbic acid, but not dehydroascorbic acid increases intracellular vitamin C content to decrease Hypoxia Inducible Factor-1 alpha activity and reduce malignant potential in human melanoma [J].
Fischer, Adam P. ;
Miles, Sarah L. .
BIOMEDICINE & PHARMACOTHERAPY, 2017, 86 :502-513
[9]   Phase I safety trial of intravenous ascorbic acid in patients with severe sepsis [J].
Fowler, Alpha A., III ;
Syed, Aamer A. ;
Knowlson, Shelley ;
Sculthorpe, Robin ;
Farthing, Don ;
DeWilde, Christine ;
Farthing, Christine A. ;
Larus, Terri L. ;
Martin, Erika ;
Brophy, Donald F. ;
Gupta, Seema ;
Fisher, Bernard J. ;
Natarajan, Ramesh .
JOURNAL OF TRANSLATIONAL MEDICINE, 2014, 12
[10]  
Garcia Maria G, 2018, Oncotarget, V9, P25922, DOI 10.18632/oncotarget.25406