Cytochrome P-450: Functions and regulation

被引：0
|
作者：
Kobliakov, VA [1 ]
机构：
[1] Russian Acad Med Sci, Blokhin Russian Canc Res Ctr, Moscow, Russia
来源：
BIOLOGICHESKIE MEMBRANY | 2003年 / 20卷 / 03期
关键词：
D O I：
暂无
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Review is devoted to the problems of cytochrome P-450 functions and regulation of expression of isoforms be longing to families 1-3 taking part in metabolism of xenobiotics. The substrate specificity of isoforms of these families in described; special attention is given to isoforms found in humans. Different mechanisms of cytochrome P-450 isoforms induction are analyzed and the role of Ah receptor in regulation of cell functions not associated with cytochrome P-450 induction are discussed. In mechanisms of common regulation of different classes of detoxification enzymes such as: monooxygenase enzyme system, conjugation enzymes and P-glycoprotein are reviewed.
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页码：265 / 272
页数：8
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