Interconversion of Hydroxylated and Methoxylated Polybrominated Diphenyl Ethers in Japanese Medaka

被引：92

作者：

Wan, Yi ^{[1
]}

Liu, Fengyan ^{[1
]}

Wiseman, Steve ^{[1
]}

Zhang, Xiaowei ^{[1
]}

Chang, Hong ^{[1
]}

Hecker, Markus ^{[1
,2
]}

Jones, Paul D. ^{[1
,3
]}

Lam, Michael H. W. ^{[4
,5
]}

Giesy, John P. ^{[1
,4
,5
,6
,7
,8
,9
,10
]}

机构：

[1] Univ Saskatchewan, Toxicol Ctr, Saskatoon, SK S7N 5B3, Canada

[2] ENTRIX Inc, Saskatoon, SK S7N 5B3, Canada

[3] Univ Saskatchewan, Sch Environm & Sustainabil, Saskatoon, SK S7N 5C8, Canada

[4] City Univ Hong Kong, State Key Lab Marine Pollut, Hong Kong, Hong Kong, Peoples R China

[5] City Univ Hong Kong, Dept Biol & Chem, Hong Kong, Hong Kong, Peoples R China

[6] Univ Saskatchewan, Dept Vet Biomed Sci, Saskatoon, SK S7N 5B3, Canada

[7] Michigan State Univ, Dept Zool, E Lansing, MI 48824 USA

[8] Michigan State Univ, Ctr Integrat Toxicol, E Lansing, MI 48824 USA

[9] King Saud Univ, Dept Zool, Coll Sci, Riyadh 11451, Saudi Arabia

[10] Univ Hong Kong, Sch Biol Sci, Hong Kong, Hong Kong, Peoples R China

来源：

ENVIRONMENTAL SCIENCE & TECHNOLOGY | 2010年 / 44卷 / 22期

基金：

加拿大自然科学与工程研究理事会; 加拿大创新基金会;

关键词：

BROMINATED FLAME RETARDANTS; WHALE DELPHINAPTERUS-LEUCAS; GLAUCOUS GULLS; ORGANOHALOGEN; BIOTRANSFORMATION; CONTAMINANTS; METABOLITES; BIOACCUMULATION; IDENTIFICATION; TRANSTHYRETIN;

D O I：

10.1021/es102287q

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Polybrominated diphenyl ethers (PBDEs), hydroxylated (OH) and methoxylated (MeO), have been widely detected in aquatic environments. However, relationships among these structurally related compounds in exposed organisms are unclear. To elucidate biotransformation relationships among BDE-47, 6-OH-BDE-47, and 6-MeO-BDE-47, dietary accumulation, maternal transfer, and tissue distribution of these compounds and their transformation products were investigated in sexually mature Japanese medaka (Oryzias latipes). In addition, transformation of each compound was determined in vitro using liver microsomes of medaka. OH-PBDEs and MeO-PBDEs were not detected in fish exposed to BDE-47. However, significant concentrations of 6-OH-BDE-47 were detected in medaka or microsomes exposed to 6-MeO-BDE-47. Significant concentrations of 6-MeO-BDE-47 were also measured in fish exposed to 6-OH-BDE-47, but 6-MeO-BDE-47 was not detected in microsomes exposed to 6-OH-BDE-47. Similar patterns of transformation products were observed in medaka eggs from adult fish during exposure. This study presents direct in vivo evidence of biotransformation of 6-MeO-BDE-47 to 6-OH-BDE-47. In addition, this is the first study to demonstrate biotransformation of 6-OH-BDE-47 to 6-MeO-BDE-47. Demethylation of 6-MeO-BDE-47 was the primary transformation pathway leading to formation of 6-OH-BDE-47 in medaka, while the previously hypothesized formation of OH-PBDEs from synthetic BDE-47 did not occur. Biotransformation products formed in adult female medaka were transferred to eggs.

引用

页码：8729 / 8735

页数：7

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