DNA-ligand interactions gained and lost: light-induced ligand redistribution in a supramolecular cascade

被引：45

作者：

Berdnikova, Daria V. ^{[1
,2
]}

Aliyeu, Tseimur M. ^{[2
]}

Paululat, Thomas ^{[1
]}

Fedorov, Yuri V. ^{[2
]}

Fedorova, Olga A. ^{[2
]}

Ihmels, Heiko ^{[1
]}

机构：

[1] Univ Siegen, Dept Chem Biol, Organ Chem 2, D-57068 Siegen, Germany

[2] Russian Acad Sci, AN Nesmeyanov Inst Organoelement Cpds, Moscow 119991, Russia

来源：

CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 23期

关键词：

HOST-GUEST COMPLEXES; DOUBLE-STRANDED DNA; BETA-CYCLODEXTRIN; DRUG-DELIVERY; BINDING; RELEASE; CELLS;

D O I：

10.1039/c5cc01025j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A supramolecular five-component cascade is presented that enables light-controlled transport of an in situ modified ligand between three host systems based on the different complexation preferences of cyclodextrin, cucurbituril, and double-stranded DNA. The results point out novel approaches for the control of drug-DNA interactions in DNA-targeting therapy.

引用

页码：4906 / 4909

页数：4

共 50 条

[1] Photoswitched DNA-binding of a photochromic spiropyran [J].

Andersson, Johanna ;

Li, Shiming ;

Lincoln, Per ;

Andreasson, Joakim .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2008, 130 (36) :11836-11837

[2] Targeted drug delivery to tumors: Myths, reality and possibility [J].

Bae, You Han ;

Park, Kinam .

JOURNAL OF CONTROLLED RELEASE, 2011, 153 (03) :198-205

[3] Controlled Delivery Systems: From Pharmaceuticals to Cells and Genes [J].

Balmayor, Elizabeth Rosado ;

Azevedo, Helena Sepulveda ;

Reis, Rui L. .

PHARMACEUTICAL RESEARCH, 2011, 28 (06) :1241-1258

[4] Cucurbituril-Induced Supramolecular pKa Shift in Fluorescent Dyes and Its Prospective Applications [J].

Barooah, Nilotpal ;

Mohanty, Jyotirmayee ;

Pal, Haridas ;

Bhasikuttan, Achikanath C. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES INDIA SECTION A-PHYSICAL SCIENCES, 2014, 84 (01) :1-17

[5] Photoinduced in situ generation of a DNA-binding benzothiazoloquinolinium derivative [J].

Berdnikova, Daria ;

Fedorova, Olga ;

Gulakova, Elena ;

Ihmels, Heiko .

CHEMICAL COMMUNICATIONS, 2012, 48 (38) :4603-4605

[6] Tuning the binding of coumarin 6 with DNA by molecular encapsulators: effect of β-cyclodextrin and C-hexylpyrogallol[4] arene [J].

Chandrasekaran, Sowrirajan ;

Sameena, Yousuf ;

Enoch, Israel V. .

JOURNAL OF MOLECULAR RECOGNITION, 2014, 27 (11) :640-652

[7] A ternary supramolecular system containing a boronated DNA-metallointercalator, β-cyclodextrin and the hexanucleotide d(GTCGAC)2 [J].

Ching, H. Y. Vincent ;

Buck, Damian P. ;

Bhadbhade, Mohan ;

Collins, J. Grant ;

Rendina, Louis M. .

CHEMICAL COMMUNICATIONS, 2012, 48 (06) :880-882

[8] Photochemically driven intercalation of small molecules into DNA by in situ irradiation [J].

Di Pietro, Maria Letizia ;

Puntoriero, Fausto ;

Tuyeras, Fabien ;

Ochsenbein, Philippe ;

Laine, Philippe P. ;

Campagna, Sebastiano .

CHEMICAL COMMUNICATIONS, 2010, 46 (28) :5169-5171

[9] Photoinduced guest transformation promotes translocation of guest from hydroxypropyl-β-cyclodextrin to cucurbit[7]uril [J].

Fedorov, Yuri V. ;

Tkachenko, Sergey V. ;

Chernikova, Ekaterina Yu ;

Godovikov, Ivan A. ;

Fedorova, Olga A. ;

Isaacs, Lyle .

CHEMICAL COMMUNICATIONS, 2015, 51 (07) :1349-1352

[10] Light-Operated Mechanized Nanoparticles [J].

Ferris, Daniel P. ;

Zhao, Yan-Li ;

Khashab, Niveen M. ;

Khatib, Hussam A. ;

Stoddart, J. Fraser ;

Zink, Jeffrey I. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2009, 131 (05) :1686-+

← 1 2 3 4 5 →