DNA-ligand interactions gained and lost: light-induced ligand redistribution in a supramolecular cascade

被引：43
作者：
Berdnikova, Daria V. [1 ,2 ]
Aliyeu, Tseimur M. [2 ]
Paululat, Thomas [1 ]
Fedorov, Yuri V. [2 ]
Fedorova, Olga A. [2 ]
Ihmels, Heiko [1 ]
机构：
[1] Univ Siegen, Dept Chem Biol, Organ Chem 2, D-57068 Siegen, Germany
[2] Russian Acad Sci, AN Nesmeyanov Inst Organoelement Cpds, Moscow 119991, Russia
来源：
CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 23期
关键词：
HOST-GUEST COMPLEXES; DOUBLE-STRANDED DNA; BETA-CYCLODEXTRIN; DRUG-DELIVERY; BINDING; RELEASE; CELLS;
D O I：
10.1039/c5cc01025j
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A supramolecular five-component cascade is presented that enables light-controlled transport of an in situ modified ligand between three host systems based on the different complexation preferences of cyclodextrin, cucurbituril, and double-stranded DNA. The results point out novel approaches for the control of drug-DNA interactions in DNA-targeting therapy.
引用
收藏
页码：4906 / 4909
页数：4
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