Aberrant DNA methylation of genomic regions translocated in myeloid malignancies

被引：0
作者：
Litz, CE [1 ]
Etzell, J [1 ]
机构：
[1] Univ Minnesota, Sch Med, Minneapolis, MN 55455 USA
来源：
LEUKEMIA & LYMPHOMA | 1998年 / 30卷 / 1-2期
关键词：
aberrant DNA methylation; genomic regions; translocations; myeloid malignancies; APL; CML; leukemias;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The mechanism of aberrant genetic recombinatorial events in neoplasia is vaguely understood. One hypothesis is that aberrant DNA methylation may in some way predispose genomic regions to recombination. Using the t(9;22) of chronic myeloid leukemia (CML) and the t(15;17) of acute promyelocytic leukemia (APL) as models, our laboratory and others have gathered data supporting this hypothesis. These data are reviewed.
引用
收藏
页码：1 / 9
页数：9
相关论文
共 34 条
[1]   DNA METHYLATION - THE EFFECT OF MINOR BASES ON DNA PROTEIN INTERACTIONS [J].
ADAMS, RLP .
BIOCHEMICAL JOURNAL, 1990, 265 (02) :309-320
[2]  
BENN P, 1988, AM J HUM GENET, V43, pA75
[3]   THE ESSENTIALS OF DNA METHYLATION [J].
BIRD, A .
CELL, 1992, 70 (01) :5-8
[4]   INDUCTION OF CHRONIC MYELOGENOUS LEUKEMIA IN MICE BY THE P210BCR/ABL GENE OF THE PHILADELPHIA-CHROMOSOME [J].
DALEY, GQ ;
VANETTEN, RA ;
BALTIMORE, D .
SCIENCE, 1990, 247 (4944) :824-830
[5]  
ETZELL J, 1997, UNPUB ABERRANT METHY
[6]   MULTIPLE METHYLATION-FREE ISLANDS FLANK A SMALL BREAKPOINT CLUSTER REGION ON 11P13 IN THE T(11-14)(P13-Q11) TRANSLOCATION [J].
FORONI, L ;
BOEHM, T ;
LAMPERT, F ;
KANEKO, Y ;
RAIMONDI, S ;
RABBITTS, TH .
GENES CHROMOSOMES & CANCER, 1990, 1 (04) :301-309
[7]   PHILADELPHIA CHROMOSOMAL BREAKPOINTS ARE CLUSTERED WITHIN A LIMITED REGION, BCR, ON CHROMOSOME-22 [J].
GROFFEN, J ;
STEPHENSON, JR ;
HEISTERKAMP, N ;
DEKLEIN, A ;
BARTRAM, CR ;
GROSVELD, G .
CELL, 1984, 36 (01) :93-99
[8]   PYRIMIDINE 5-METHYL GROUPS INFLUENCE THE MAGNITUDE OF DNA CURVATURE [J].
HAGERMAN, PJ .
BIOCHEMISTRY, 1990, 29 (08) :1980-1983
[9]   STRUCTURAL ORGANIZATION OF THE BCR GENE AND ITS ROLE IN THE PH' TRANSLOCATION [J].
HEISTERKAMP, N ;
STAM, K ;
GROFFEN, J ;
DEKLEIN, A ;
GROSVELD, G .
NATURE, 1985, 315 (6022) :758-761
[10]   CPG METHYLATED MINICHROMOSOMES BECOME INACCESSIBLE FOR V(D)J RECOMBINATION AFTER UNDERGOING REPLICATION [J].
HSIEH, CL ;
LIEBER, MR .
EMBO JOURNAL, 1992, 11 (01) :315-325
1234