A new strategy for the synthesis of 4,6-di-tert-butyl-2,2-dipentyl-2,3-dihydro-5-benzofuranol (BO-653), a potent antiatherogenic antioxidant

被引：7

作者：

Murakata, Masatoshi ^{[1
]}

Kimura, Masahiro ^{[1
]}

机构：

[1] Chugai Pharmaceut Co Ltd, API Proc Dev Dept, Kita Ku, Tokyo 1158543, Japan

来源：

TETRAHEDRON LETTERS | 2010年 / 51卷 / 38期

关键词：

GRIGNARD-REAGENT; BROMIDE; DESIGN; CONSTITUTION; MECHANISM; ETHER;

D O I：

10.1016/j.tetlet.2010.07.035

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient alternative route to 4,6-di-tert-butyl-2,2-dipentyl-2,3-dihydro-5-benzofuranol (BO-653), a potent antiatherogenic antioxidant, has been developed by the application of the base-promoted dienone-phenol rearrangement reaction. A decisive effect of MgBr(2) in the reaction of Grignard reagents is also described. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：4950 / 4952

页数：3

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