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- [11] A multicenter, randomized, double-blind, parallel-group trial of the antihypertensive efficacy and tolerability of a combination of once-daily Losartan 100mg/hydrochlorothiazide 12.5 mg compared with Losartan 100-mg monotherapy in the treatment of mild to severe essential hypertension CLINICAL THERAPEUTICS, 2006, 28 (10) : 1639 - 1648